Drug metabolism and transport are pivotal in determining the efficacy, safety, and pharmacokinetics of therapeutic compounds. Recent advancements in understanding these pathways and transporters have significantly contributed to the development of innovative drugs. Key metabolic enzymes and transporters have been identified, which are implicated in various human diseases, and there have been advancements in regulatory guidance for in vivo and in vitro studies of these proteins. This progress is evident in recent drug approvals, such as prodrugs, hydrolases in beta-lactam antibiotic combinations, and inhibitors like odevixibat and ertugliflozin. Despite these advancements, challenges remain in optimizing drug delivery, necessitating a multidisciplinary approach that includes technological advances, computational modeling, personalized medicine, and collaborative research efforts. Addressing these challenges is crucial for improving therapeutic outcomes and minimizing adverse effects.

This research topic aims to outline the importance of new drug development strategies and address the challenges faced in drug metabolism and transport. The primary objectives include optimizing drug delivery systems to enhance stability, bioavailability, and tissue-specific targeting, overcoming biological barriers, and addressing drug resistance. Additionally, the research seeks to understand the role of gut microbiota in drug metabolism and integrate systems biology to tackle the complexity of drug metabolism networks. Adhering to regulatory guidance for in vitro and in vivo testing is also a key focus to ensure the efficacy and safety of newly developed therapeutic entities.

To gather further insights in the field of drug metabolism and transport, we welcome articles addressing, but not limited to, the following themes:

- Optimizing drug delivery systems, such as liposomes, nanoparticles, and prodrugs.
- Strategies to overcome biological barriers, including the blood-brain barrier.
- Addressing drug resistance through the modulation of drug transporters.
- The impact of genetic variations and drug-drug interactions on drug efficacy and safety.
- The involvement of gut microbiota in drug metabolism and its implications for personalized medicine.
- Integration of systems biology for a comprehensive understanding of drug metabolism networks.
- Adhering to regulatory guidance for in vitro and in vivo testing to ensure compliance and safety.

This collection welcomes submissions of the following article types: Brief Research Report (submission in the Experimental Pharmacology section only), Clinical Trial (submission in the Drug Metabolism and Transport section only), Correction, Data Report, Editorial, General Commentary, Hypothesis & Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Technology and Code.

Topic Editor Dr. Charles OO is the founder of SunLife Biopharma Consult.

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Frontiers in Pharmacology

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