Frontiers | New Drugs and Future Challenges in Drug Metabolism and Transport

New Drugs and Future Challenges in Drug Metabolism and Transport

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ORIGINAL RESEARCH

Accepted on 20 Jan 2025

Pharmacokinetics and Bioequivalence of Two Formulations of S-1 (Tegafur/Gimeracil/Oxonate) Capsule in Chinese Cancer Subjects under Fasting and Fed Conditions: a Multicenter, Randomized, Open, Single-dose, Double-Cycle Crossover Study

Junli Lu
Yuyan Lei
Yuanyuan Mo
Xiangping Wang
Wanying Liu
Yu Yan
Hongying Yang
Canxia Li
Lifeng Huang
4 more
Xiaohui Li

doi 10.3389/fphar.2025.1494902

ORIGINAL RESEARCH

Published on 08 Jan 2025

The efficacy and safety of remimazolam besylate, ciprofol, and propofol during hysteroscopy

Weifeng Shan
Shuying Gao
Mengting Ai
Haiyan Lan
Gongchen Duan
Xiaoli Dong
Qiaomin Xu
Yini Wu
Jimin Wu

doi 10.3389/fphar.2024.1427755

218 views

ORIGINAL RESEARCH

Published on 08 Jan 2025

The in vivo metabolic pathway of Deg-AZM and in vitro investigations into the contribution of drug metabolizing enzymes and drug transporters in the drug interactions of Deg-AZM, a clinical-stage new transgelin agonist

Xiaoting Gu
Xiaohe Li
Weixue Tian
Chaoyue Zheng
Yutian Cai
Xiang Xu
Conglu Zhao
Hongting Liu
Yao Sun
4 more
Cheng Yang

doi 10.3389/fphar.2024.1510903

198 views

ORIGINAL RESEARCH

Accepted on 27 Dec 2024

Novel (Q)SAR Models for Prediction of Reversible and Time-Dependent Inhibition of Cytochrome P450 Enzymes Authors

Sadegh Faramarzi
Arianna Bassan
Kevin P Cross
Xinning Yang
Glenn J Myatt
Donna Volpe
Lidiya Stavitskaya

doi 10.3389/fphar.2024.1451164

ORIGINAL RESEARCH

Published on 04 Dec 2024

Development of a UPLC-MS/MS method for the determination of sulfatinib and its no interaction with myricetin in rats

Dongxin Chen
Jie Chen
Hailun Xia
Xiaohai Chen
Jinyu Hu
Guangliang Wu
Xuegu Xu

doi 10.3389/fphar.2024.1498339

235 views

ORIGINAL RESEARCH

Published on 03 Dec 2024

Coptisine enhances the sensitivity of chemoresistant breast cancer cells by inhibiting the function and expression of ABC transporters

Safaa Yehia Eid

doi 10.3389/fphar.2024.1472458

345 views

ORIGINAL RESEARCH

Published on 03 Dec 2024

Computational studies for pre-evaluation of pharmacological profile of gut microbiota-produced gliclazide metabolites

Maja Đanić
Nebojša Pavlović
Dragana Zaklan
Bojan Stanimirov
Slavica Lazarević
Hani Al-Salami
Momir Mikov

doi 10.3389/fphar.2024.1492284

324 views

ORIGINAL RESEARCH

Published on 07 Nov 2024

In vitro, in vivo, and in silico approaches for evaluating the preclinical DMPK profiles of ammoxetine, a novel chiral serotonin and norepinephrine reuptake inhibitor

Xiuqing Zhu
Yuexin Li
Huan Luo
Yunxia Zhang
Zhenqing Zhang
Jinglai Li

doi 10.3389/fphar.2024.1486856

604 views

REVIEW

Published on 23 Oct 2024

Porphyrin-engineered nanoscale metal-organic frameworks: enhancing photodynamic therapy and ferroptosis in oncology

Yutao Zou
Jiayi Chen
Xuanxuan Luo
Yijie Qu
Mengjiao Zhou
Rui Xia
Weiqi Wang
Xiaohua Zheng

doi 10.3389/fphar.2024.1481168

576 views

ORIGINAL RESEARCH

Published on 26 Aug 2024

Preclinical pharmacokinetic studies and prediction of human PK profiles for Deg-AZM, a clinical-stage new transgelin agonist

Xiaoting Gu
Xiaohe Li
Weixue Tian
Chaoyue Zheng
Yutian Cai
Xiang Xu
Conglu Zhao
Hongting Liu
Yao Sun
4 more
Cheng Yang

doi 10.3389/fphar.2024.1423175

718 views

ORIGINAL RESEARCH

Published on 07 Aug 2024

The effect of pregnancy-related hormones on hepatic transporters: studies with premenopausal human hepatocytes

Jhohann Richard de Lima Benzi
Yik Pui Tsang
Jashvant D. Unadkat

doi 10.3389/fphar.2024.1440010

1,239 views
1 citation

ORIGINAL RESEARCH

Published on 22 Jul 2024

A new crystalline daidzein-piperazine salt with enhanced solubility, permeability, and bioavailability

Jiacheng Meng
Chenxu Qiu
Chenyue Lu
Xin He
Xinghua Zhao

doi 10.3389/fphar.2024.1385637

841 views

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Frontiers in Pharmacology

Drug Metabolism and Transport
Experimental Pharmacology and Drug Discovery

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Articles

Pharmacokinetics and Bioequivalence of Two Formulations of S-1 (Tegafur/Gimeracil/Oxonate) Capsule in Chinese Cancer Subjects under Fasting and Fed Conditions: a Multicenter, Randomized, Open, Single-dose, Double-Cycle Crossover Study

The efficacy and safety of remimazolam besylate, ciprofol, and propofol during hysteroscopy

The in vivo metabolic pathway of Deg-AZM and in vitro investigations into the contribution of drug metabolizing enzymes and drug transporters in the drug interactions of Deg-AZM, a clinical-stage new transgelin agonist

Novel (Q)SAR Models for Prediction of Reversible and Time-Dependent Inhibition of Cytochrome P450 Enzymes Authors

Development of a UPLC-MS/MS method for the determination of sulfatinib and its no interaction with myricetin in rats

Coptisine enhances the sensitivity of chemoresistant breast cancer cells by inhibiting the function and expression of ABC transporters

Computational studies for pre-evaluation of pharmacological profile of gut microbiota-produced gliclazide metabolites

In vitro, in vivo, and in silico approaches for evaluating the preclinical DMPK profiles of ammoxetine, a novel chiral serotonin and norepinephrine reuptake inhibitor

Porphyrin-engineered nanoscale metal-organic frameworks: enhancing photodynamic therapy and ferroptosis in oncology

Preclinical pharmacokinetic studies and prediction of human PK profiles for Deg-AZM, a clinical-stage new transgelin agonist

The effect of pregnancy-related hormones on hepatic transporters: studies with premenopausal human hepatocytes

A new crystalline daidzein-piperazine salt with enhanced solubility, permeability, and bioavailability

Frontiers in Pharmacology

Submit your idea

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