Non-Alcoholic Steatohepatitis (NASH), a complex and aggressive form of non-alcoholic fatty liver disease (NAFLD), presents with hepatic inflammation and fibrosis. A pivotal but underexplored aspect of NASH pathogenesis involves the role of adaptive immunity. Specific adaptive immune cells, including various T cell and B cell subsets, are involved in inflammatory responses, contributing to both hepatic injury and repair. These adaptive immune components interact with the innate immune system, creating a sophisticated immune network that influences NASH progression. Understanding these complex interactions is crucial for unraveling NASH's underlying mechanisms.

The primary goal of this Research Topic is to dissect and elucidate the multifaceted roles of adaptive immune regulation in NASH. This includes understanding how different T cell subsets (exhausted CD8, effector CD8, memory CD8, Th1, Th2, Th17, and Tregs, etc.) balance pro-inflammatory and anti-inflammatory responses, the involvement of B cells in antibody-mediated reactions, and the cross-talk between adaptive and innate immunity through mechanisms such as Toll-like receptor signalling. Recent advances have paved the way for exploring adaptive immunity in NASH, yet comprehensive insights remain fragmented. By assembling an integrated perspective on adaptive immune mechanisms in NASH, this Research Topic aims to foster translational research that leverages these insights into diagnostic biomarkers and personalized therapeutic strategies.

This Research Topic seeks to cultivate a diverse and in-depth exploration of the adaptive immune regulation of NASH. We invite submissions from a broad spectrum, including Original Research, Systematic Review, Methods, Review and Mini-Review, Clinical Trial, Hypothesis & Theory articles. Contributions should focus on but are not limited to:
• Characterization of T cell and B cell subsets and their roles in NASH.
• Molecular mechanisms underlying adaptive immune responses in NASH, including cytokines, chemokines, and signaling pathways.
• Interplay between adaptive and innate immunity, including the roles of myeloid-derived suppressor cells and innate lymphoid cells.
• Clinical applications of adaptive immune insights, such as biomarker discovery, therapeutic targeting, and potential links with other immune-mediated inflammatory diseases (IMIDs).
• Ethical, clinical, and translational considerations in the study and treatment of NASH through adaptive immunity.

Manuscripts describing traditional or alternative medicine are out of scope for this Research Topic.

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Frontiers in Immunology

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