Health-Related Quality of Life (HRQoL) in neuro-oncological patients is a complex and multifaceted area of study that intersects medicine and health. It is influenced by a range of factors, including physical, emotional, and cognitive aspects. Despite the growing interest in this field, driven by the concept of precision medicine, the integration of HRQoL principles into everyday clinical decision-making remains a challenge. This is particularly true in the context of neuro-oncological diseases and other life-changing neurological impairments. The need for a paradigm shift in clinical practice is evident, as the current approach often overlooks the importance of maintaining patients' general well-being, as emphasized in the revised ""Geneva Declaration"" of 2017.

The primary objective of this research topic is to provide an integrative, up-to-date overview of HRQoL in adult and pediatric patients with neuro-oncological diseases. This includes diseases affecting both the central and peripheral nervous system. The research aims to shed light on the significant impact of diagnosis, prognosis, and potential toxicity of therapies on patients' HRQoL and daily-living activities. It also seeks to explore the uneven integration of advances in radiation oncology, immuno- and chemotherapy, advanced neuroimaging, and neuromodulation into clinical practice. The research will focus on the specific challenges of HRQoL in neuro-oncological populations, which have often been marginalized within the broader context of cancer.

To further explore the complexities of HRQoL in neuro-oncological patients, this research topic will focus on intrinsic tumours of the nervous system, excluding metastases. The following themes are of particular interest:

- The impact of diagnosis and prognosis on HRQoL
- The influence of therapy toxicity on HRQoL and daily-living activities
- The integration of advances in treatment strategies into clinical practice
- The specific challenges of HRQoL in neuro-oncological populations
- The HRQoL associated with non-cerebral neuro-oncological diseases

Please note that manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases, which are not accompanied by validation, are out of scope for this section and will not be accepted as part of this Research Topic.

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Frontiers in Oncology

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