In the dynamic field of neuroscience, the introduction and utilization of human induced pluripotent stem cells (hiPSCs) have heralded a new era for studying neurodevelopmental disorders (NDDs). These models have led to significant breakthroughs in delineating the intricate mechanisms that underpin these disorders, yet they still present substantial challenges that obstruct a comprehensive understanding. Issues such as measuring the balance of neuronal excitation and inhibition, delineating transcriptional dysregulation, and addressing abnormalities in protein trafficking and chromatin structures remain as significant hurdles. These factors are critical for both envisioning the pathophysiology of NDDs and for the practical applications of this knowledge in developing targeted therapies and diagnostics.

This research topic aims to delve into the latest innovations in hiPSC technology, building on recent advances in gene editing and 3D organoid culture, among others. The central goal is to overcome existing methodological limitations by employing sophisticated microscopy, multi-electrode arrays, and the integration of multi-omics approaches to paint a fuller picture of the underlying pathomechanisms of NDDs. Through these methods, the research seeks to enhance the fidelity and utility of hiPSC models and extend their application across varied research settings.

To gather further insights into the high-resolution analysis of human models of neurodevelopmental disorders, we welcome articles addressing, but not limited to, the following themes:
- Rare and ultra-rare genetic neurodevelopmental disorders
- Paradigms and preparations validated across laboratories
- Long-term cultures, co-culture systems, and 3D brain organoids
- Microfluidics and Organ-on-a-Chip Systems
- Novel protocols and techniques for advanced imaging, including optogenetics and High-Throughput Screening
- Integration of multi-omics data, encompassing genomics, transcriptomics, proteomics, and metabolomics

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Frontiers in Neuroscience

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