Glycome is composed of all the glycosylated and glycan molecules which produced through the biosynthetic process of bioglycosylation. We now know that all types of cells including prokaryotes (e.g., archaea and bacteria) and eukaryotes (e.g., mammals) encompass the effective process of glycosylation. Hence, glycans -the sugar-based polymers are effective molecules for production of glycoproteins. Glycans contribute to vital activities including immune system and the related responses, cell-to-cell signaling, host-pathogen interactions. In this regard, glycoconjugates can be considerable biomarkers in a wide range of autoimmune diseases glycobiology, cancer glycobiology, cancer immunotherapy glycobiology, infectious diseases glycobiology, biopharmaceutics glycobiology, vaccines glycobiology, systems glycobiology, microbial glycobiology, chemical glycobiology, synthetic glycobiology, etc.

Recently, prokaryotic glycoproteins have also been attracted for their glycan and linkage differences from eukaryotes. For example, bacterial glycoconjugates greatly can promotes our understanding to a deep insight to structural and glycosylation basis. The prokaryotic glycan information may help to open a new vista of interactions and innate immune responses between prokaryotes and their hosts.

Recent studies in the field of glycobiology and in particular systems glycobiology have revealed that the glycome of healthy body and all types of diseases like cancers possess their own glycan profilings which can be recognized as significant patterns. It seems that detection, identification and recognition of glycan profilings in association with healthy bodies or different types of diseases may lead us to find out effective biomarkers for stronger diagnostics, metabolisms, immunotherapies, biopharmaceutics, vaccines, etc.

As aforementioned, glycobiology as an interdisciplinary science involves a wide range of research fields. This research topic aims to involve all the cases associated with autoimmune diseases glycobiology, cancer glycobiology, cancer immunotherapy glycobiology, evolutional Glycobiology, innate immune Glycobiology, infectious diseases glycobiology, biopharmaceutics glycobiology, vaccines glycobiology, systems glycobiology, microbial glycobiology, chemical glycobiology, synthetic glycobiology, etc. Hence, a wide range of items are regarded in the present Research Topic.

-Glycobiology of Health and homeostasis condition
-----Age
-----Females and Males
-----Glycan profiling
-----Immune system
-----Glycomics
-----Microbiome
-----Metabolism
-----Predisposing factors

-Glycobiology of diseases
-----Infectious diseases
-----Autoimmune diseases
-----Cancers
-----Glycan profiling
-----Biomarkers (glycosylated molecules)
-----Glycomics

-Glycobiology of treatment and prevention
-----Immunotherapy
-----T cell therapy
-----Biopharmaceutics
-----Vaccines
-----Glycomics
-----Genetics
-----Epigenetics

-Systems glycobiology
-----Drug target discovery
-----Glycoengineering
-----Cell engineering
-----High-throughput glycol-analytical technologies
-----Profiling tools

-Microbial glycobiology
-----Glycans and host-microbe interactions in healthy people
-----Glycans and host-microbe interactions in unhealthy people
-----Glycans and microbiome composition in human homeostasis
-----Glycans diversity and evolutional differences in organisms

-Chemical glycobiology
-----Enzymes
-----Chemical and biochemical tools and techniques
-----Regulators and inhibitors of glycosyltransferases and glycosidases

-Synthetic glycobiology
-----Glycorecombination
-----Synthetic glycans
-----Synthetic glycans synthesis systems
-----Glycoprotein engineering
-----Carbohydrates engineering

Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic.

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Frontiers in Immunology

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