About this Research Topic
This Research Topic aims to understand the control mechanisms for how the immune cells are delivered to the target tissues for immune surveillance and pathology, and the discovery of novel interventions for the treatment of chronic inflammatory, autoimmune diseases and cancer. Our focuses include 1) the mechanisms that control vascular endothelial cell specialization, particularly venular endothelial cells that display specific adhesion molecules and chemokines mediating the extravasation of immune cells from the circulation to target tissues; 2) how the immune cells acquire their specific “homing” abilities to the target tissues, particularly on lymphocyte homing receptors (chemokine receptors and integrins) that direct the migration of immune cells.
The goal of this Research Topic is to:
1) To understand the genetic and environmental control of organotypic and segmental endothelial cell phenotypes and specialization, which determines the sites, pace, and specificity of leukocyte recruitment from the blood.
2) To understand the development and trafficking of white blood cells (e.g. lymphocytes, dendritic cells), including their interactions with the endothelial lining of blood vessels at sites of leukocyte extravasation, their chemotactic responses in tissues, and their programming by environmental factors in lymphoid tissues and within mucosal surfaces.
The scope is on fundamental mechanisms for organotypic and tissue-specific leukocytes trafficking and the related pathology. We are preferably targeting on manuscripts focusing on molecular and cellular discoveries, genetic studies, disease models and translational approaches. We accept the following article types: Original Research, Systematic Review, Methods, Review, Hypothesis & Theory, Clinical Trial, Classification, Technology and Code, Study Protocol, Mini Review, Perspective, Case Report, Conceptual Analysis, Curriculum, Instruction, and Pedagogy, Brief Research Report, Data Report, General Commentary and Opinion.
The goal of this Research Topic is to:
1) To understand the genetic and environmental control of organotypic and segmental endothelial cell phenotypes and specialization, which determines the sites, pace, and specificity of leukocyte recruitment from the blood.
2) To understand the development and trafficking of white blood cells (e.g. lymphocytes, dendritic cells), including their interactions with the endothelial lining of blood vessels at sites of leukocyte extravasation, their chemotactic responses in tissues, and their programming by environmental factors in lymphoid tissues and within mucosal surfaces.
The scope is on fundamental mechanisms for organotypic and tissue-specific leukocytes trafficking and the related pathology. We are preferably targeting on manuscripts focusing on molecular and cellular discoveries, genetic studies, disease models and translational approaches. We accept the following article types: Original Research, Systematic Review, Methods, Review, Hypothesis & Theory, Clinical Trial, Classification, Technology and Code, Study Protocol, Mini Review, Perspective, Case Report, Conceptual Analysis, Curriculum, Instruction, and Pedagogy, Brief Research Report, Data Report, General Commentary and Opinion.
Keywords: Endothelial Cell Specialization, Leukocyte Adhesion, Chemotaxis, Lymphocyte Homing
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
