The integration of synthetic biology with studies on immune responses in barrier tissues represents a burgeoning field of research with significant implications for therapeutic and diagnostic advancements. Barrier tissues, including the skin, lungs, and gastrointestinal tract, are pivotal in maintaining health and mediating disease processes. Recent studies have highlighted the potential of synthetic biology to revolutionize our understanding and manipulation of these tissues. However, despite these advancements, there remain critical gaps in our knowledge, particularly concerning the spatial and mechanistic intricacies of immune responses within these tissues. Ongoing debates focus on the efficacy and safety of synthetic biology applications, and there is a pressing need for more comprehensive investigations to address these challenges. Significant studies have begun to unravel the complexities of immune responses at barrier tissues, yet the field is ripe for further exploration to fully harness the potential of synthetic biology in this context.

This Research Topic aims to explore the intersection of synthetic biology and immune responses at barrier tissues, with a focus on advancing therapeutic and diagnostic strategies. The main objectives include elucidating the mechanistic underpinnings of immune responses in barrier tissues, developing innovative synthetic biology tools for therapeutic interventions, and enhancing diagnostic capabilities. Key questions to be addressed include how synthetic biology can be leveraged to improve our understanding of immune mechanisms and what novel methodologies can be developed to target barrier tissues effectively.

To gather further insights in the integration of synthetic biology with immune responses at barrier tissues, we welcome articles addressing, but not limited to, the following themes:

- Discoveries from single-cell sequencing techniques and their significance, especially concerning spatial location in barrier tissues.
- Development of biologics and their immunological consequences for interventions at barrier tissues.
- Innovations in mRNA delivery methods tailored for immune responses at barrier tissues.
- Dynamics and impacts of immune modulators within barrier tissues.
- Clinical studies and translational research probing the efficacy and challenges of therapeutic approaches for barrier tissues, such as those focusing on immune modulatory treatments.

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Frontiers in Immunology

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