Neuroinflammation is a crucial area of study that has garnered increasing attention in recent years due to its implications in various neurodegenerative conditions, such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis. This Research Topic aims to delve into the intricate relationship between neuroinflammation and the pathogenesis of these neurodegenerative diseases, with a primary focus on identifying novel therapeutic interventions that could mitigate or halt disease progression.

Despite considerable research progress in the field of neurodegenerative diseases, the exact underlying mechanisms and triggers remain partially understood. There is mounting evidence suggesting that neuroinflammation plays a critical role in the development and progression of these disorders. Immune-mediated inflammatory responses within the central nervous system can exacerbate neuronal damage, propagate neurodegeneration, and contribute to disease complexity. Understanding the precise interplay between neuroinflammation and neurodegenerative processes is of utmost importance for devising targeted therapies.

This Research Topic will be a comprehensive collection of literature on neuroinflammation in neurodegenerative diseases, highlighting significant findings, controversies, and gaps in our understanding. The Topic will explore, but is not limited to, the following themes:

1. Unraveling the Molecular Mechanisms: Elucidating the molecular pathways and cellular players involved in neuroinflammation, providing insights into potential therapeutic targets.

2. Inflammatory Biomarkers and Diagnostics: The utility of inflammatory biomarkers as diagnostic tools for neurodegenerative diseases and discuss their potential application in early detection and disease monitoring.

3. Therapeutic Approaches and Interventions: Promisingtherapeutic approaches to attenuate neuroinflammation and slow down the progression of neurodegenerative diseases. This may include pharmaceutical interventions, lifestyle modifications, or novel targeted therapies.

4. Neuroprotective Strategies: Neuroprotective strategies aimed at mitigating neuroinflammation-induced damage in neurodegenerative diseases and promoting neuronal survival in vivo.

We will extend an invitation to researchers and experts in the field of neuroinflammation and neurodegenerative diseases to contribute their valuable insights to this Research Topic. We encourage studies encompassing both preclinical and clinical research, as well as interdisciplinary approaches that bridge the gap between basic science and translational applications.

By shedding light on the intricate relationship between neuroinflammation and neurodegenerative diseases, this Research Topic aspires to pave the way for the development of novel therapeutic interventions. The findings from this collective effort could lead to a paradigm shift in the management of these devastating neurological conditions, ultimately improving the quality of life for affected individuals and their families.

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Frontiers in Neuroscience

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