Hypoxia has been a topical issue in biological research, both in aquatic and terrestrial animals. A sufficient oxygen concentration is essential for electron transport within the mitochondria of aerobic organisms. Compared with terrestrial animals, marine fish live in an aquatic environment where dissolved oxygen fluctuates more drastically and frequently. Therefore, to some extent, fish are a better model for hypoxia research. Aquatic ecosystems are being stressed by nutrient enrichment, pollutants, and global warming, leading to a serious depletion in oxygen concentrations. However, the current research on hypoxia in fish is relatively underdeveloped, which mainly focuses on the changes in physiological and biochemical levels, and oxygen sensing protein expression. Further studies on fish hypoxia will help to reveal the mechanism of hypoxic response in fish, and provide more insights into hypoxia research in the life of the sea.

Screening and validation of hypoxia candidate genes are essential to revealing the molecular mechanism of hypoxia. Although some of the current fish omics studies have initially screened the candidate genes, these results are incomplete and need to be further explored. It is important to further narrow down the candidate gene screening based on integrated multi-omics analysis techniques and validate the candidate genes with CRISPR/Cas9 and other validation techniques for future hypoxia research.

This Research Topic will mainly focus on the physiological, biochemical and molecular mechanisms of fish under hypoxia stress, topics include (but not limited to) the following sub-topics:

1. Effects of hypoxic stress on the physiochemistry of fish.
2. Genomic approaches in the physiological or biochemistry studies in fish hypoxic responses.
3. Application of integrated multi-omics analysis to the molecular mechanism of hypoxic response in fish.
4. Identification and functional validation of hypoxia candidate genes and pathways.
5. Development and utilization of hypoxia-related molecular markers.

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Frontiers in Marine Science

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