Metal ions exhibit very important roles in the biological environment. Inorganic chemistry, and the related field of medicinal inorganic chemistry, has shown to be one of the best routes to create excellent drugs that can be used and help in therapy or the diagnosis of diseases. Introduction of metal ions or metal ion binding components (complexes) into a biological system for the treatment of diseases is a primary subdivision in this field. This intentional introduction of the metal ions into the human-biological systems has found to be very useful for both diagnostic and therapeutic purposes. Metallodrugs are considered to be prodrugs which undergo activation by ligand substitution or redox reactions. Schiff base derivatives and their transition metal complexes have proved to have exceptional applications as precursors for potential reagents for drugs which may be used to cure a variety of diseases, such bacterial and fungal infections, inflammation, and cancer maladies. Many researchers have adopted the investigation of Schiff bases and their complexes and correlated with their research the possible applications in drug design and drug discovery.

Recently, bioinorganic, and medicinal chemists have focused on Schiff bases and their transition metal complexes to investigate their potential pharmacological applications. A broad range of biological activities, such as anti-bacterial, anti-fungal, anti-viral, anti-inflammatory, and anti-tumor activities are shown by these derivatives. Moreover, there is strong curiosity in synthesizing cheaper coordination compounds, such as first-row transition metal complexes, which could be potential efficient medications. Hence, we would like to highlight research presenting syntheses of complexes of Schiff base ligands with different transition metal species and possible therapeutics agent properties in this Research Topic.

We welcome the submission of Original Research articles, Reviews, Mini-Reviews and Perspectives on themes that include, but are not limited to:

- Molecular design, synthesis, and characterization of transition metal complexes of new Schiff base ligands
- Structure elucidation by single crystal X-ray analysis, theoretical studies (such as DFT) and In Silico molecular simulations for the derivatives.
- The Biological applications of these complexes such as antimicrobial, antiviral and anticancer properties.
- Antioxidant activities, fluorescence quenching studies, intercalative mode for DNA interaction, DNA binding potency and DNA cleavage as well as molecular docking studies.
- Drug design and drug discovery of newly reported complexes.

Submit your idea

Impact

Frontiers in Chemistry

Submit your idea

Impact