In the last decade, extracellular vesicles (EVs) have emerged as a promising field of research due to their ability to participate in cell-to-cell communication. Released by virtually all cell types, EVs have a complex cargo that includes proteins, lipids, mRNAs and non-coding RNA, and by delivering it to both surrounding and distant cells, EVs act as mediators of cell signaling, capable of modifying the recipient cell phenotype. EVs can reflect the nature and physiological state of the cell of origin and, as such, they may not only play a pivotal role in the cellular events that culminate into disease, but also hold great potential as drug delivery vehicles and biomarkers. However, we are only starting to understand how EVs are part of the paracrine, reciprocal signaling between cells and how they may dictate the recipient cell phenotype via the transfer of their very diverse and complex cargo.
This research topic aims to collect work that will add to a better understanding of EVs as potential therapeutic agents in pathological conditions and/or as circulating/systemic biomarkers for diseases. We welcome manuscripts, describing either fundamental or applied research, that contribute to the understanding of how EVs can be actively explored as natural drug delivery systems and powerful shuttles for the delivery of therapeutic agents. Priority will be accorded to studies that rigorously characterize the specific cargo components within EVs responsible for therapeutic effects, shedding light on the mechanistic underpinnings of their action. Furthermore, manuscripts are encouraged to discuss the translational aspects of this knowledge, exploring its applicability in clinical settings.
We invite submissions in the form of primary research articles, review articles, as well as systematic reviews and meta-analyses. More specifically, we welcome works focusing on the following areas:
• Omics technologies, which facilitate discovery or support claims regarding biomarkers, therapeutic targets, functional molecules, mechanism of actions, biological/pathophysiologic processes, or therapeutic responses.
• Comprehensive characterization and comparison of EVs subtypes
• Investigating EVs biomarkers in the context of clinical research
• Large-scale validation of EVs biomarkers using clinically compatible assays, i.e., ELISA, high-resolution flow cytometry, NanoString nCounter, etc.
• Therapeutic efficacy of EVs or EVs-mimics bearing functional moieties with or without genetic engineering
• EVs as a stem cell-free therapy
• EVs study in disease models in vitro or in vivo
This Research Topic encourages the authors to follow the minimal information for studies of extracellular vesicles 2018 (MISEV2018) guidelines established by the International Society of Extracellular Vesicles (www.isev.org) for reporting their EV study.
Keywords:
Extracellular Vesicles, Biomarkers, Treatment, non-coding RNA, Omics.
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
In the last decade, extracellular vesicles (EVs) have emerged as a promising field of research due to their ability to participate in cell-to-cell communication. Released by virtually all cell types, EVs have a complex cargo that includes proteins, lipids, mRNAs and non-coding RNA, and by delivering it to both surrounding and distant cells, EVs act as mediators of cell signaling, capable of modifying the recipient cell phenotype. EVs can reflect the nature and physiological state of the cell of origin and, as such, they may not only play a pivotal role in the cellular events that culminate into disease, but also hold great potential as drug delivery vehicles and biomarkers. However, we are only starting to understand how EVs are part of the paracrine, reciprocal signaling between cells and how they may dictate the recipient cell phenotype via the transfer of their very diverse and complex cargo.
This research topic aims to collect work that will add to a better understanding of EVs as potential therapeutic agents in pathological conditions and/or as circulating/systemic biomarkers for diseases. We welcome manuscripts, describing either fundamental or applied research, that contribute to the understanding of how EVs can be actively explored as natural drug delivery systems and powerful shuttles for the delivery of therapeutic agents. Priority will be accorded to studies that rigorously characterize the specific cargo components within EVs responsible for therapeutic effects, shedding light on the mechanistic underpinnings of their action. Furthermore, manuscripts are encouraged to discuss the translational aspects of this knowledge, exploring its applicability in clinical settings.
We invite submissions in the form of primary research articles, review articles, as well as systematic reviews and meta-analyses. More specifically, we welcome works focusing on the following areas:
• Omics technologies, which facilitate discovery or support claims regarding biomarkers, therapeutic targets, functional molecules, mechanism of actions, biological/pathophysiologic processes, or therapeutic responses.
• Comprehensive characterization and comparison of EVs subtypes
• Investigating EVs biomarkers in the context of clinical research
• Large-scale validation of EVs biomarkers using clinically compatible assays, i.e., ELISA, high-resolution flow cytometry, NanoString nCounter, etc.
• Therapeutic efficacy of EVs or EVs-mimics bearing functional moieties with or without genetic engineering
• EVs as a stem cell-free therapy
• EVs study in disease models in vitro or in vivo
This Research Topic encourages the authors to follow the minimal information for studies of extracellular vesicles 2018 (MISEV2018) guidelines established by the International Society of Extracellular Vesicles (www.isev.org) for reporting their EV study.
Keywords:
Extracellular Vesicles, Biomarkers, Treatment, non-coding RNA, Omics.
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.