About this Research Topic
dysregulation may be detrimental and hence implicated in several pathological processes. In parallel, several NRs are known to protect against both acute and chronic inflammatory responses, being also likely to emerge as potential therapeutic targets.
The aim of this Research Topic is to gather novel viewpoints and results dealing with the complexity of the neuroimmunoendocrine regulatory mechanisms wherein NRs are implicated. In view of their intricate interplay and networks in which NRs play a part, the compilation and systematization of studies dealing with their involvement in physiological and pathological states are appropriate to potentiate the development of this field. In addition, manuscripts providing novel findings and standpoints about NRs will expand our current understanding of the potential therapeutic strategies for disorders related to their dysregulation. In the same sense, the contribution of NRs to the modulation of endocrine and neuro-immuno-metabolic responses also sets the basis for delineating novel intervention approaches for diseases encompassing disturbances in this regard.
In this Research Topic, we welcome original articles and reviews that cover the participation of NRs in homeostasis and pathology, and some potential therapeutic interventions. The topics we would like to include, although not limited to, are:
I. Influence and implication of NRs in physiological circuits.
II. Participation of NRs in the crosstalk between the endocrine and neuro-immuno-metabolic response in health and disease.
III. Effects of hormones and other ligands on NR regulation.
IV. Design of novel therapeutic approaches involving NRs.
Keywords: Nuclear Receptors, Hormones, Immunoendocrine Response, gene regulation, cell signalling
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.