The retina is a part of central nervous system. Although it is known as an immune
privilege tissue, the pathogenesis of retinal diseases frequently involves intrinsic and
extrinsic immune responses. There have been several dramatic recent innovations in the
study of disease mechanisms and drug-development in the field of Ophthalmology.
These include advancements in single cell identification, high resolution confocal
microscopy, a genome-wide framework to draw gene regulation and signal pathways,
and identification of small molecules for therapeutic potential.
This Research Topic aims to include how innate and adaptive immune cells interact with
the retinal cells and neurons physiologically, and disease pathogenesis, tissue repair,
and novel therapeutic potentials. With the inclusion of basic science as well as clinical
trial data, the collection aims to serve as a valuable resource to researchers and
clinicians, and accelerate the communication of current research achievements in the
field of the retinal diseases.
This Research Topic will solicit the discovery of novel immune functions of neuronal
retinal cells: such as photoreceptor cells (rods and cones), retinal ganglion cells, bipolar
cells, horizontal cells, amacrine cells, Muller cells, or astrocytes, microglial cells, retinal
pigment epithelial cells (RPE), retinal vascular endothelial cells, innate lymphocytes, and
resident macrophages. The detailed events will include retinal cellular synaptic
connections, regulating neuronal circuits, phagocytizing cell debris, morphogenic effect,
cytokine/growth factor secretions, extra-cellular vehicles (EVs), exosomes in various
animal models, inflammatory, and degenerative retinal diseases.
Keywords:
immune reactive cells, retina, Inflammation, neuronal retinal cells
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
The retina is a part of central nervous system. Although it is known as an immune
privilege tissue, the pathogenesis of retinal diseases frequently involves intrinsic and
extrinsic immune responses. There have been several dramatic recent innovations in the
study of disease mechanisms and drug-development in the field of Ophthalmology.
These include advancements in single cell identification, high resolution confocal
microscopy, a genome-wide framework to draw gene regulation and signal pathways,
and identification of small molecules for therapeutic potential.
This Research Topic aims to include how innate and adaptive immune cells interact with
the retinal cells and neurons physiologically, and disease pathogenesis, tissue repair,
and novel therapeutic potentials. With the inclusion of basic science as well as clinical
trial data, the collection aims to serve as a valuable resource to researchers and
clinicians, and accelerate the communication of current research achievements in the
field of the retinal diseases.
This Research Topic will solicit the discovery of novel immune functions of neuronal
retinal cells: such as photoreceptor cells (rods and cones), retinal ganglion cells, bipolar
cells, horizontal cells, amacrine cells, Muller cells, or astrocytes, microglial cells, retinal
pigment epithelial cells (RPE), retinal vascular endothelial cells, innate lymphocytes, and
resident macrophages. The detailed events will include retinal cellular synaptic
connections, regulating neuronal circuits, phagocytizing cell debris, morphogenic effect,
cytokine/growth factor secretions, extra-cellular vehicles (EVs), exosomes in various
animal models, inflammatory, and degenerative retinal diseases.
Keywords:
immune reactive cells, retina, Inflammation, neuronal retinal cells
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.