Personalized medicine approaches to allergic diseases

Allergic diseases exemplified by atopic dermatitis, food allergy, allergic rhinitis, and allergic asthma affect hundreds of millions of people around the world and the incidence of these conditions has increased dramatically over the last few decades. Allergic diseases have their origins in early life, which represents a crucial period of heightened plasticity where the developing immune system and gut microbiome are shaped by interactions between genes and environmental factors. The advent of powerful systems biology tools enables the unbiased study of the intervening biology that connects environmental factors with cellular and molecular systems and emergent phenotypic traits, which in turn will inform the development of personalized medicine approaches to the early detection, treatment and/or prevention of these diseases.

The objective of this Research Topic is to present the latest findings from basic science and translational research that will inform the development of personalized medicine approaches to the treatment or prevention of allergic diseases.
• Gene-by-environmental interactions that underpin the development and/or pathogenesis of allergic diseases
• Immunometabolic pathways that contribute to the development and/or pathogenesis of allergic diseases
• Novel endotypes of allergic diseases
• Novel molecular mechanisms underlying allergic diseases
• Novel approaches to the diagnosis or early identification of high-risk individuals
• Novel approaches to the treatment or prevention of allergic diseases
• Drug repurposing studies for the treatment of allergic diseases.
• Biomarker studies to identify responders and nonresponders to current or emerging therapies

All article types accepted by Frontiers are welcome.

Keywords: allergy, asthma, immunology, microbiome, personalized medicine, omics, systems biology

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.