About this Research Topic
Enzymes are essential biological catalysts that play a critical role in numerous biochemical processes. Understanding the structure-function relationship of enzymes is of paramount importance, as it provides insights into their mechanisms, substrate specificity, and regulation. By uncovering the intricate details of how enzymes function at a molecular and chemical level, we gain valuable knowledge that can be applied in various fields, including biotechnology, drug discovery, and metabolic engineering.
This Research Topic aims to delve into the structure-function relationship of enzymes through a chemical lens, focusing on the interplay between enzyme structure, dynamics, and function. We seek to explore the latest advancements in this area and identify key challenges that remain to be addressed. By elucidating the underlying principles governing enzyme activity and specificity, we can develop novel strategies for enzyme engineering, improve biocatalysis, and enhance our understanding of enzymatic processes in biological systems.
In this Research Topic we invite submissions addressing, but not limited to, the following themes:
• Elucidation of enzyme structures and their dynamics using advanced structural, spectroscopic, and chemical biology techniques.
• Investigation of enzyme catalytic mechanisms and substrate binding interactions.
• Understanding the role of cofactors, metal ions, and small molecules in enzyme function.
• Application of computational methods, molecular modeling, and simulations to study enzyme chemistry, dynamics and function.
• Engineering and redesign of enzymes for improved catalytic efficiency, specificity, and stability.
This Research Topic aims to delve into the structure-function relationship of enzymes through a chemical lens, focusing on the interplay between enzyme structure, dynamics, and function. We seek to explore the latest advancements in this area and identify key challenges that remain to be addressed. By elucidating the underlying principles governing enzyme activity and specificity, we can develop novel strategies for enzyme engineering, improve biocatalysis, and enhance our understanding of enzymatic processes in biological systems.
In this Research Topic we invite submissions addressing, but not limited to, the following themes:
• Elucidation of enzyme structures and their dynamics using advanced structural, spectroscopic, and chemical biology techniques.
• Investigation of enzyme catalytic mechanisms and substrate binding interactions.
• Understanding the role of cofactors, metal ions, and small molecules in enzyme function.
• Application of computational methods, molecular modeling, and simulations to study enzyme chemistry, dynamics and function.
• Engineering and redesign of enzymes for improved catalytic efficiency, specificity, and stability.
Keywords: Enzymes, Structure-function relationship, Enzyme dynamics, Enzyme catalysis, Enzyme engineering
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
