About this Research Topic
Non-coding RNAs (ncRNAs) have emerged as critical players in the development and progression of gynecological cancers. These cancers, including ovarian, cervical, uterine and endometrial, vaginal, and vulvar cancers, pose significant challenges in terms of treatment and prognosis. Therefore, understanding the intricate involvement of ncRNAs in the pathogenesis of gynecological cancers opens up new avenues for improved cancer therapy and prognosis.
Different classes of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), etc have been shown to modulate fundamental cellular processes, such as cell proliferation, apoptosis, angiogenesis, invasion, and metastasis, contributing to the development and progression of gynecological malignancies. Understanding the specific roles of ncRNAs in these processes will provide valuable insights into the underlying mechanisms of gynecological cancer pathogenesis. Moreover, the identification of specific ncRNA signatures associated with different types and stages of gynecological cancers holds promise for the development of non-invasive diagnostic tests and individualized treatment approaches. NcRNAs present unique opportunities for the development of innovative therapeutic strategies, including RNA-based therapeutics, that aim to modulate their expression or activity. Exploring the potential of targeting ncRNAs in combination with conventional therapies or as standalone treatments opens new possibilities for improving outcomes in gynecological cancer patients.
This Research Topic aims to provide a comprehensive overview of the roles of ncRNAs in gynecological cancers, focusing on the latest research findings and the potential implications for cancer therapy and prognosis. By shedding light on the complex regulatory roles of ncRNAs in cancer pathogenesis, we aim to accelerate the translation of ncRNA-based discoveries into clinical applications, ultimately transforming the landscape of gynecological cancer therapy and prognosis.
We welcome contributions from researchers and clinicians that provide state-of-the-art insights into the involvement of ncRNAs in gynecological cancers, encouraging the submission of high-quality manuscripts that address the latest advancements, challenges, and future directions in understanding the role of ncRNAs in gynecological cancers.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Different classes of ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), etc have been shown to modulate fundamental cellular processes, such as cell proliferation, apoptosis, angiogenesis, invasion, and metastasis, contributing to the development and progression of gynecological malignancies. Understanding the specific roles of ncRNAs in these processes will provide valuable insights into the underlying mechanisms of gynecological cancer pathogenesis. Moreover, the identification of specific ncRNA signatures associated with different types and stages of gynecological cancers holds promise for the development of non-invasive diagnostic tests and individualized treatment approaches. NcRNAs present unique opportunities for the development of innovative therapeutic strategies, including RNA-based therapeutics, that aim to modulate their expression or activity. Exploring the potential of targeting ncRNAs in combination with conventional therapies or as standalone treatments opens new possibilities for improving outcomes in gynecological cancer patients.
This Research Topic aims to provide a comprehensive overview of the roles of ncRNAs in gynecological cancers, focusing on the latest research findings and the potential implications for cancer therapy and prognosis. By shedding light on the complex regulatory roles of ncRNAs in cancer pathogenesis, we aim to accelerate the translation of ncRNA-based discoveries into clinical applications, ultimately transforming the landscape of gynecological cancer therapy and prognosis.
We welcome contributions from researchers and clinicians that provide state-of-the-art insights into the involvement of ncRNAs in gynecological cancers, encouraging the submission of high-quality manuscripts that address the latest advancements, challenges, and future directions in understanding the role of ncRNAs in gynecological cancers.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords: ncRNAs, pathogenesis, cancer therapy, cancer prognosis, translational research, clinical applications
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
