About this Research Topic
Chronic Hepatitis B Virus (HBV) infection remains a significant global health concern. Amid the relentless march of medical research, strategies for managing chronic hepatitis B (CHB) are undergoing a transformation. They are transcending the conventional role of merely suppressing HBV DNA replication towards achieving a clinical cure or functional cure. A clinical cure of CHB represents a culmination of specific achievements: the absence of detectable HBV DNA, seroconversion of HBV surface antigen (HBsAg), and the restoration of liver function to normal parameters. This multi-dimensional success not only signifies the cessation of viral replication but also holds the promise of averting ominous complications like cirrhosis and hepatocellular carcinoma.
However, the path to this achievement is strewn with challenges. Resilient viral reservoirs, especially covalently closed circular DNA (cccDNA), have been subverting conventional therapeutic tactics. Future research necessitates delving deeper into viral biology and host responses, achieving a paradigm shift from merely managing symptoms to envisioning a virus-free existence and clinical cure.
The primary goal of this Research Topic is to propel our understanding of the persistent HBV infection. We aim to explore strategies that could further optimize the path to recovery for patients suffering from chronic Hepatitis B, providing more effective, personalized, and comprehensive approaches for CHB clinical cure. Authors are encouraged to share their valuable research findings and authoritative insights to enrich our grasp of chronic HBV infection, while concurrently driving advancement across the dimensions of diagnosis, treatment and prophylaxis. Specifically, we invite submissions of Original Research or Reviews encompassing a spectrum of subtopics, including, but not limited to:
• Innovative medications and nascent strategies for achieving clinical cure of CHB
• Exploration of improving post-attainment patient outcomes following clinical cure of CHB
• Pathogenesis of Chronic Hepatitis B and related novel biomarkers for predicting clinical cure
However, the path to this achievement is strewn with challenges. Resilient viral reservoirs, especially covalently closed circular DNA (cccDNA), have been subverting conventional therapeutic tactics. Future research necessitates delving deeper into viral biology and host responses, achieving a paradigm shift from merely managing symptoms to envisioning a virus-free existence and clinical cure.
The primary goal of this Research Topic is to propel our understanding of the persistent HBV infection. We aim to explore strategies that could further optimize the path to recovery for patients suffering from chronic Hepatitis B, providing more effective, personalized, and comprehensive approaches for CHB clinical cure. Authors are encouraged to share their valuable research findings and authoritative insights to enrich our grasp of chronic HBV infection, while concurrently driving advancement across the dimensions of diagnosis, treatment and prophylaxis. Specifically, we invite submissions of Original Research or Reviews encompassing a spectrum of subtopics, including, but not limited to:
• Innovative medications and nascent strategies for achieving clinical cure of CHB
• Exploration of improving post-attainment patient outcomes following clinical cure of CHB
• Pathogenesis of Chronic Hepatitis B and related novel biomarkers for predicting clinical cure
Keywords: Hepatitis B Virus, Chronic Hepatitis B, Clinical Cure, Treatment, Pathogenesis
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