Stem Cells and Biomaterials as Tissue-Engineered Scaffolds in Dental Applications

Tissue regeneration refers to the performance of the combination of stem cells, biomolecules and scaffolds into oral damaged tissues. scaffold constructs that allow the growth of cells and tissues have been studied for the restoration of damaged oral soft and hard tissues. Several conditions must be affected to achieve the promoted functional improvement. Biomaterials have affected the connection through the graft in the assistance of damaged contacts for cell proliferation and work as a vehicle to transport dental stem cells (DSCs) to alter the microenvironment. DSCs, possessing the capacity for self-renewal and multicellular differentiation, promise new strategies for the treatment of damaged tissue mechanisms by secret trophic factors or by the improper renewal of stem cells and their supporting factors. Scaffolds have increased DSCs in vivo and in vitro, proposing the cells with the

This research initiative is centered around investigating the pharmacological impacts and underlying mechanisms associated with Biomaterials and/or stem cells, encompassing a spectrum from fundamental scientific exploration to practical clinical translational investigations. We cordially invite authors to contribute their Original Research, Review, Opinion, and Perspective articles, with a specific focus on the subsequent but not exhaustive subtopics:

• Exploration of the roles and pharmacological effects exerted by Biomaterials and/or dental stem cells within diverse biological processes, spanning from organogenesis to angiogenesis;
• Examination of the practical applications of Biomaterials and/or dental stem cells in the domain of dental bone and nerve development and regeneration, alongside an in-depth analysis of the concomitant pharmacological effects and intricate mechanisms at play;
• Deliberation on the potential therapeutic roles of Biomaterials and/or stem cells in addressing periodontal diseases, substantiated by rigorous exploration of the associated pharmacodynamics;
• Thorough investigation into the roles and pharmacological influences of Biomaterials and/or dental stem cells in the prevention and mitigation of aging-associated conditions, with an emphasis on the underlying biological mechanisms;
• Scrutiny of the roles and pharmacological implications attributed to Biomaterials and/or dental stem cells during early developmental stages, particularly in the context of organogenesis within dental implant.

Keywords: Integrative and Regenerative Pharmacology, stem cell, Biomaterials, Scaffold

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