Metabolic disorders, such as type 2 diabetes, hyperlipidemia, and Hyperuricemia, are a group of diseases that involve metabolic disorders. Metabolic and Hemodynamics factors are thought to be the main causes of damage to large and microvessels, including the heart, brain, arms and legs, kidneys, and retina. In recent years, the prevalence of metabolic vascular disease is increasing rapidly. In addition, metabolic vascular disease is a leading cause of blindness, kidney failure, heart attack, stroke, and lower limb amputation, and contributes to an increase in premature mortality worldwide. Recent studies have shown that immune and inflammatory responses are involved in the activation of chromatin remodeling (apoptosis, pyroptosis, necroptosis, ferroptosis, and NETs) and inflammation in a variety of diseases and epigenetics, such as non-coding RNAs, histone modifications, DNA methylation, and programmed cell death, a novel mechanism of gut microbiota-mediated immunoregulation. However, the role of epigenetics and gut microbiota in metabolic vascular disease and new drugs that target oxidative stress based on these factors remains unknown.

In this special issue, we encourage researchers to submit original research and review articles, this article focuses on the molecular mechanisms of immuno-inflammatory responses in the development of metabolic vascular diseases, the roles of epigenetics, gut microbiota, and cell programmed death in the regulation of balance and metabolic vascular diseases, and the role of new drugs targeting immune/inflammatory responses in the treatment and prevention of metabolic vascular diseases.

Potential topics include but are not limited to the following:

• Molecular mechanisms of immunomodulatory remodeling in vascular injury and metabolic vascular disease

• The role of inflammation-induced programmed cell death, such as apoptosis, pyroptosis, necroptosis, ferroptosis, NETs, and autophagy, in metabolic vascular diseases

• The role of immunity in regulating inflammatory activation and resolution and metabolic vascular disease

• Epigenetics, such as non-coding RNA, histone modifications, DNA methylation, chromatin remodeling, etc., are important in immune or inflammatory regulation and metabolic vascular diseases

• the role of gut microbes and metabolites in the regulation of inflammation and metabolic vascular diseases

• Metabolic Disorders of blood glucose, lipids, and amino acids lead to oxidative stress and metabolic vascular diseases

• New drugs targeting immune or inflammatory responses to prevent and treat metabolic vascular diseases

• new mechanisms of inflammation-induced endothelial dysfunction in diabetic vascular complications

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserve the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Frontiers in Molecular Biosciences

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