About this Research Topic
Dietary management of tumor-bearing hosts can impact pathological outcomes with many studies focusing on host and gut microbial metabolism impact on the immune system. Diets are shown to impact metabolism of the target organ, e.g., the tumor (focus of this Research Topic) or distant sites (systemic organs) via the supply of micro and macronutrients. Diets' direct influence on the microbial communities (gut and oral microbiome) can also modulate tumor progression and patients’ response to cancer treatments. Significantly, microbiota can influence the anti-cancer compounds' stability, toxicity, and efficacy in cancer patients. Also, the role of gut microbiome as a clinical predictor in immune-related adverse events is appreciated. Thus, dietary-based microbial modulation has a diverse impact on tumor progression, which needs to be carefully assessed to develop effective cancer therapeutics. This Research Topic aims to review the evidence for dietary-based interventions on tumor progression and therapeutic outcomes via direct (immune or metabolic) or indirect (modulation of the microbiome and in turn the immune system) mechanisms. This review will advance the field and help identify critical mechanisms/players for future investigations as well as develop better nutritional-based therapeutic tools for cancer patients.
This Research Topic welcomes Review/Mini Review articles in the field of dietary (specific diets or dietary patterns) or microbiome-based studies in tumor models, including but not limited to the following areas:
• Dietary-based interventions in tumor models
• Impact of diet on local and systemic immunity in tumor studies
• Dietary-based metabolic perturbation in the tumor microenvironment
• Diet and gut microbiome interaction in tumor metabolism
• Role of the oral microbiome in tumor immunity and metabolism
• Impact of diet and microbiome on therapeutic response to cancer
Keywords: Gut Microbiota, Diet, Metabolism, Tumor immunity, tumor microenvironment, cancer immunotherapies, oral microbiome, microbiome
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.