The field of chemical biology has increasingly focused on the occurrence and determination of natural toxins in food samples, a critical area of research given the potential health risks associated with these compounds. Current problems in this field include the need for more sensitive and accurate detection methods, as well as a deeper understanding of the molecular mechanisms by which these toxins exert their effects. Recent studies have made significant strides in identifying and characterizing various natural toxins, such as mycotoxins, and their impact on human health. However, gaps remain in our knowledge, particularly regarding the biosynthetic pathways of these toxins and their interactions with biological systems. Addressing these gaps is essential for developing effective strategies to mitigate the risks posed by natural toxins in food.

This research topic aims to explore the intricate interface between chemical biology and natural toxins in food samples. The main objectives are to unravel the molecular mechanisms underlying toxin formation, elucidate their effects on biological systems, and devise innovative strategies for ensuring food safety. Specific questions include: What are the chemical properties and biological interactions of these toxins? How can we develop more effective detection and monitoring methods? What are the toxicological implications of these compounds?

To gather further insights into the occurrence and determination of natural toxins in food samples, we welcome original articles, perspectives and reviews addressing, but not limited to, the following themes:
- Development of analytical strategies based on miniaturized processes for the determination and evaluation of natural toxins in food samples.
- Chemical characterization and structural elucidation of natural toxins in food matrices.
- Identification of molecular targets and mechanisms of action of natural toxins in biological systems.
- Development of innovative chemical probes and biosensors for toxin detection and monitoring.
- Evaluation of the impact of natural toxins on cellular signalling pathways and physiological processes.
- Application of chemical biology approaches for understanding toxin-host interactions and host defence mechanisms.
- Investigation of the biosynthetic pathways and enzymatic reactions involved in natural toxin production.
- Occurrence of mycotoxins and other natural toxins in food samples.

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Frontiers in Chemical Biology

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