About this Research Topic
Maintenance of perfusion to the brain and other vital organs is critical for patient outcomes in acute care. Cerebral perfusion may be compromised by states of shock, hypotension, hypovolemia, and reduced cardiac output, and result in increased mortality and morbidity. Cerebral perfusion is traditionally considered to be unaffected by marked changes in blood pressure due to cerebral autoregulation, but new insights demonstrate that cerebral blood flow may be affected by modest changes in blood pressure and by e.g. vasoactive medication and changes in blood volume. Knowledge of central hemodynamics and the effect on the cerebral circulation may help guide clinical therapy, inspire future research, and improve outcomes.
The goal of the article collection is to advance our understanding of the cerebral circulation in the hemodynamically unstable patient. This may be in relation to e.g. bleeding, hypovolemia, sepsis, volume- and vasopressor therapy in addition to anesthesia, surgery, and pharmacological and orthostatic interventions. Various novel and established techniques are used in the field to evaluate brain perfusion and oxygenation and to assess indices of cerebral autoregulation and cerebrovascular reactivity. Authors may also assess the effect on the circulation of other organs and organ markers, imaging parameters, and clinical outcomes in order to advance our understanding of cerebral perfusion in the hemodynamically challenged patient.
The article collection is open to manuscripts on the effect of hemodynamic changes on cerebral perfusion, including original research papers, reviews, and case reports. Manuscripts should evaluate cerebral perfusion and or oxygenation and may also assess the effect on other organs such as the heart, kidneys, liver, muscle, and skin. The research setting may be clinical, in healthy volunteers, or in animal models.
The goal of the article collection is to advance our understanding of the cerebral circulation in the hemodynamically unstable patient. This may be in relation to e.g. bleeding, hypovolemia, sepsis, volume- and vasopressor therapy in addition to anesthesia, surgery, and pharmacological and orthostatic interventions. Various novel and established techniques are used in the field to evaluate brain perfusion and oxygenation and to assess indices of cerebral autoregulation and cerebrovascular reactivity. Authors may also assess the effect on the circulation of other organs and organ markers, imaging parameters, and clinical outcomes in order to advance our understanding of cerebral perfusion in the hemodynamically challenged patient.
The article collection is open to manuscripts on the effect of hemodynamic changes on cerebral perfusion, including original research papers, reviews, and case reports. Manuscripts should evaluate cerebral perfusion and or oxygenation and may also assess the effect on other organs such as the heart, kidneys, liver, muscle, and skin. The research setting may be clinical, in healthy volunteers, or in animal models.
Keywords: Anaesthesia, Blood Pressure, Cerebral Blood Flow, Cerebrovascular Circulation, Hypertension, Organ Blood Flow
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