Neuroimmunology, the interdisciplinary field at the intersection of neuroscience and immunology, has emerged as a vital area of research with profound implications for understanding the complex interplay between the immune system and the central nervous system (CNS). The field of neuroimmunology has witnessed significant advancements with the advent of organoids, and three-dimensional in vitro models that mimic the cellular composition and functions of the human organs, including the CNS or the immune system. These remarkable structures accurately recapitulate key cellular components and functional characteristics, allowing researchers to investigate the complex interactions between immune cells, glial cells, and neuronal networks in a controlled and representative environment.
Through this comprehensive Research Topic, we aim to highlight the transformative potential of organoids as a powerful tool in advancing our understanding of Neuroimmunology and offering potential avenues for therapeutic interventions. The collection will cover various subtopics, including the cell biology and heterogeneity of brain and immune organoids, their application in understanding neuroinflammatory diseases such as multiple sclerosis, the role of glial cells in neuroinflammation, the immune response to infections, models for studying neurotoxicity in adoptive immune cell therapies, and the inflammatory response in the CNS to systemic diseases.
Topic Editor Sara Garcia Gil-Perotin received financial support from Sanofi, Roche, Merck, Biogen and Bristol Myers Squibb. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
The Team of Topic Editors would like to knowledge the assistance of MD Lucas Barea Moya on this Research Topic.
Keywords:
Cerebral organoids, neuroimmunology, immune, neuroinflammation, multiple sclerosis, glia
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Neuroimmunology, the interdisciplinary field at the intersection of neuroscience and immunology, has emerged as a vital area of research with profound implications for understanding the complex interplay between the immune system and the central nervous system (CNS). The field of neuroimmunology has witnessed significant advancements with the advent of organoids, and three-dimensional in vitro models that mimic the cellular composition and functions of the human organs, including the CNS or the immune system. These remarkable structures accurately recapitulate key cellular components and functional characteristics, allowing researchers to investigate the complex interactions between immune cells, glial cells, and neuronal networks in a controlled and representative environment.
Through this comprehensive Research Topic, we aim to highlight the transformative potential of organoids as a powerful tool in advancing our understanding of Neuroimmunology and offering potential avenues for therapeutic interventions. The collection will cover various subtopics, including the cell biology and heterogeneity of brain and immune organoids, their application in understanding neuroinflammatory diseases such as multiple sclerosis, the role of glial cells in neuroinflammation, the immune response to infections, models for studying neurotoxicity in adoptive immune cell therapies, and the inflammatory response in the CNS to systemic diseases.
Topic Editor Sara Garcia Gil-Perotin received financial support from Sanofi, Roche, Merck, Biogen and Bristol Myers Squibb. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
The Team of Topic Editors would like to knowledge the assistance of MD Lucas Barea Moya on this Research Topic.
Keywords:
Cerebral organoids, neuroimmunology, immune, neuroinflammation, multiple sclerosis, glia
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.