Neuroimmunology sits at the crossroads of neuroscience and immunology, increasingly recognized for its crucial role in elucidating the interactions between the immune system and the central nervous system (CNS). This field has seen substantial leaps forward with the introduction of brain organoids. These three-dimensional in vitro models authentically mimic human organular structures such as the CNS, offering a precise representation of cellular diversity and functionality. This innovative tool enables an in-depth examination of the intricate communications between immune cells, glial cells, and neuronal circuits, providing a unique window into physiological and pathological processes.

The goal of this Research Topic is to underscore the significant impact of brain organoids in neuroimmunological research and their potential to revolutionize therapeutic strategies. We aim to investigate how these models can illuminate the underlying mechanisms of neuroinflammatory diseases, critique current neuroinflammatory responses, and potentially offer avenues for novel treatments.

This Research Topic will explore a range of pertinent issues within the sphere of neuroimmunology:

• Investigating the cell biology and heterogeneity of brain and immune organoids.
• Exploring neuroinflammatory diseases such as multiple sclerosis.
• Analyzing the role of glial cells in neuroinflammation.
• Examining the immune response to infections.
• Studying the applications of organoids in neurotoxicity and adoptive immune cell therapies.
• Assessing the CNS's inflammatory response to systemic diseases.

By delving deep into these areas, this collection aims to provide comprehensive insights into both the capabilities and the future potential of brain organoids in advancing the field of neuroimmunology.

The Team of Topic Editors would like to acknowledge the assistance of MD Lucas Barea Moya on this Research Topic.

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Frontiers in Cellular Neuroscience

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