Emerging evidence indicated environmental stress factors, such as outdoor/indoor air pollution, climate change, heavy metals and emerging contaminants, are closely associated with the development of multiple human diseases. Particularly, epidemiological and animal model studies have consistently linked air pollutants primarily derived from stationary and traffic-related combustion sources, such as PM2.5, benzene, and ozone, to the increase of mortality and morbidity associated with endocrine-related diseases including cardiometabolic disorder. Even some of the environmental challenges act as endocrine disruptors to disturb the synthesis, secretion, transportation and function of hormones. Thus, “environmental challenges and endocrine dysregulation” is a global and timely topic of discussion.

In the past decades, intensive research efforts and significant progress have been made in elucidating the effects and mechanisms by which environmental challenge contributes to the initiation and progression of endocrine dysregulation and relevant diseases. To promote the biomedical and public health research communication, it is urgent and necessary to explore the association, mechanism and intervention of the environment-related diseases from the view of endocrine function.

The important topics in this area include but are not limited to:
• Adverse effects of air pollution, climate change and endocrine disrupting chemicals on predisposition to endocrine diseases
• Hormonal- or transmitter-mediated stress responses to environmental challenges that modulate endocrine and metabolic functions
• Mechanistic links or mechanistic basis for environmental stressors, endocrine dysregulation and cardiometabolic diseases
• Interactions between genetic, environmental, and psychiatric factors in endocrine diseases
• Interventions, including both traditional medicine and modern medicine, on endocrine-related diseases induced by environmental challenges
• The role of endocrine disruption triggered by environmental factors in the developmental, reproductive, neurological, cardiovascular, and metabolic disorders.

The Research Topic accepts manuscripts of both Original Research and Reviews.
Special Note for authors:
To ensure the submissions that we receive are really pushing forward to understand the environmental challenges and endocrine dysfunction. We strongly recommend authors to have a look at a previous Research Topic addressing this subject “Environmental Stressors and Metabolic Disease”.

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Frontiers in Endocrinology

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