Cancer is a complex and devastating disease characterized by uncontrolled cell growth, invasion into surrounding tissues, and the potential to metastasize to distant sites in the body. Traditionally, cancer research has predominantly focused on genetic mutations as the driving force behind tumorigenesis. However, it has become increasingly evident that epigenetic modifications play a critical role in cancer development and progression. Currently, we understand epigenetic modifications which include DNA methylation, histone modifications, and non-coding RNAs can regulate gene expression patterns and influence cellular functions without changing the underlying DNA sequence. However, in cancer, these mechanisms can be significantly disrupted leading to abnormal gene expression patterns and subsequently, contributing to tumor progression.

Therefore, we urgently need to develop our understanding and unravel the complex epigenetic mechanisms underlying cancer development and progression to help develop novel therapeutic approaches and potential treatments. While significant progress has been made in unraveling genetic alterations in cancer, the role of epigenetic modifications in driving tumorigenesis remains incompletely understood. To achieve a comprehensive understanding of the epigenetic landscape of cancer, several approaches including DNA methylation analysis, histone modification profiling, and chromatin conformation capture techniques can be employed. Subsequently, researchers can gain a comprehensive understanding of the epigenetic alterations that contribute to cancer initiation, tumor heterogeneity, and potential therapeutic targets.

The goal of this Research Topic is to encompass a comprehensive exploration of the epigenetic mechanisms underlying cancer development and progression across various cancer types. The aim is to provide a broad understanding of the field, covering both fundamental and translational research aspects. The following themes are of particular interest to contributors:

-Epigenetic alterations in different cancer types and stages.

-Mechanisms of epigenetic regulation and their impact on gene expression.

-Interplay between genetic and epigenetic alterations in cancer.

-Epigenetic biomarkers for cancer diagnosis, prognosis, and therapeutic response prediction.

Please note that manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of the scope for this section and will not be accepted as part of this Research Topic.

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Frontiers in Oncology

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