About this Research Topic
Membrane Trafficking is an essential transport mechanism occurring in cells for the transport of proteins, pathogens, and other macromolecules wrapped in membrane-bound transport vesicles. This process either takes place between different organelles within the same cell or across various destinations in the cell membrane inside and outside of the cell.
Cells employ a highly regulated and complex mechanism to maintain targeted delivery of the right ‘cargo’ at the correct destination. The fundamental component of cell membranes is lipids, and their composition tends to vary within different organelle membranes, subregions, and domains within the membrane. The differential lipid distribution in these membranes is a product of local lipid metabolism or intracellular lipid transport from the place of synthesis like the endoplasmic reticulum to the destined membranes or membrane domains.
Changes in the lipid composition in the membranes or mutations in enzymes crucial to lipid biosynthesis and metabolism can affect membrane trafficking.
In this Research Topic, we are interested in exploring cutting-edge research that focuses on how membrane lipid composition is crucial for the proper functioning of membrane trafficking pathways, specifically endocytosis, and the secretory pathway.
Overall, we aim to advance our understanding of this essential component of the membrane trafficking process, which holds the key to the future of this field.
Areas of interest for this collection may include but are not limited to:
-The role of lipids with context to extracellular cues in membrane trafficking
-Indispensability of lipids for the transfer of molecules between organelles and across the plasma membrane
-How lipids in the membrane help highly differentiated cells to perform specialized cell functions related to membrane trafficking
-What part do lipids play in the regulation of membrane trafficking in the processes involved in embryonic development
-Disruption of membrane trafficking due to the alteration of lipid biosynthesis in cell membranes acting as disease hotbeds
-Use of the “Lipid Toolbox” to visualize membrane fusion events, study lipid raft dynamics, and track specific lipid species associated with different trafficking routes in live cells, isolated tissues, and subcellular fractions
This collection welcomes Original Research articles, Reviews, and Mini-reviews papers as well as Methods, and Hypothesis and Theory articles. A full list of accepted article types, including descriptions, can be found at this link.
Cells employ a highly regulated and complex mechanism to maintain targeted delivery of the right ‘cargo’ at the correct destination. The fundamental component of cell membranes is lipids, and their composition tends to vary within different organelle membranes, subregions, and domains within the membrane. The differential lipid distribution in these membranes is a product of local lipid metabolism or intracellular lipid transport from the place of synthesis like the endoplasmic reticulum to the destined membranes or membrane domains.
Changes in the lipid composition in the membranes or mutations in enzymes crucial to lipid biosynthesis and metabolism can affect membrane trafficking.
In this Research Topic, we are interested in exploring cutting-edge research that focuses on how membrane lipid composition is crucial for the proper functioning of membrane trafficking pathways, specifically endocytosis, and the secretory pathway.
Overall, we aim to advance our understanding of this essential component of the membrane trafficking process, which holds the key to the future of this field.
Areas of interest for this collection may include but are not limited to:
-The role of lipids with context to extracellular cues in membrane trafficking
-Indispensability of lipids for the transfer of molecules between organelles and across the plasma membrane
-How lipids in the membrane help highly differentiated cells to perform specialized cell functions related to membrane trafficking
-What part do lipids play in the regulation of membrane trafficking in the processes involved in embryonic development
-Disruption of membrane trafficking due to the alteration of lipid biosynthesis in cell membranes acting as disease hotbeds
-Use of the “Lipid Toolbox” to visualize membrane fusion events, study lipid raft dynamics, and track specific lipid species associated with different trafficking routes in live cells, isolated tissues, and subcellular fractions
This collection welcomes Original Research articles, Reviews, and Mini-reviews papers as well as Methods, and Hypothesis and Theory articles. A full list of accepted article types, including descriptions, can be found at this link.
Keywords: membrane trafficking, lipids, lipid biosynthesis, endocytosis, secretory pathway
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
