Single Photon Emission Computed Tomography (SPECT) and Computed Tomography (CT) are cornerstone technologies in medical imaging, each providing unique diagnostic insights. SPECT provides dynamic functional insights through gamma-ray-emitting radioactive tracers administered into patients, which, when captured by gamma cameras from various angles, yield detailed 3-D images. Conversely, CT offers precise anatomical detail using X-ray technology. The fusion of SPECT and CT not only enhances image quality through accurate attenuation correction but also significantly improves diagnostic capabilities by aligning metabolic data with high-resolution anatomical structures. This combination has proven pivotal in refining patient management and treatment strategies, yet the full potential of SPECT/CT in clinical settings remains underexplored, particularly with the advent of newer technologies and methodologies.

This Research Topic aims to explore groundbreaking innovations in SPECT/CT technologies and their integration into clinical practice. The goal is to harness these advancements to substantially improve diagnostic accuracy and patient outcomes in the context of personalized medicine. The research will focus on enhancing imaging performance through electronic innovations, novel materials, and artificial intelligence algorithms, as well as expanding the applications of SPECT/CT in new clinical domains.

To advance our understanding of these technologies' capabilities and limitations, this topic seeks contributions that span a broad spectrum of related themes. Particularly, we welcome articles that address, but are not limited to, the following:

• Technological advancements and electronic innovations in SPECT/CT;
• New materials and tools enhancing SPECT/CT imaging quality;
• Artificial intelligence applications in image reconstruction and analysis;
• Development and validation of new radioactive tracers;
• Clinical case studies demonstrating the efficacy of SPECT/CT in unique scenarios.

This collection aims to encapsulate the current trends and future directions in SPECT/CT imaging technology, fostering a deeper integration into modern medical practice.

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Frontiers in Physics

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