Regulated cell death (RCD) is a fundamental biological process that underlies many (patho)physiological traits, including organismal development, tissue homeostasis, and immune responses. Many forms of regulated cell death exist, each induced by a particular activation signal and mediated through distinct molecular mechanisms. RCD plays an integral role in the control of infections by restricting the spread of invading pathogens through the removal of infected cells and controlling activated immune cells from going awry once these have fulfilled their function. Depending on the type of RCD and strength of the activating signal, immunological consequences of RCD may vary; some forms of RCD are immunologically silent, whereas others can lead to inflammation. Recent studies have revealed interactions between RCD pathways. This has significantly broadened our understanding of how RCD pathways help control infections and inflammatory diseases, and has indicated that the pathways of RCD may be therapeutically manipulated to control diseases.

The goal of this Research Topic is to provide a comprehensive and concise overview of the various modes of regulated cell death, their involvement in the immunological control of pathogenic infections, their contribution to sterile inflammatory diseases, and how therapeutic exploitation of RCD may aid the control of infectious and immunological diseases.

We welcome the submission of Original Research, Review, Mini Review, Opinion, and Hypothesis and Theory articles, including but not limited to, the following topics:

1. The immunological consequences of RCD in the context of pathogenic infections.
2. The immunological consequences of RCD in the context of sterile inflammation and/or inflammatory diseases.
3. The immunological consequences of the interplay between the pathways of RCD.

This Research Topic is the second volume of the “Community Series in The Immunological Consequences of Regulated Cell Death in Infection and Inflammation”. Please see the first volume here.

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