About this Research Topic
Biomaterials, either of natural or synthetic origin are increasingly used in medical applications aiming at mechanical support, regeneration of tissue functions, or replacement of damaged tissue. Among medical applications, implantable devices and prostheses for patients with cardiovascular diseases (CVD) commonly utilize biomaterial components. Consequently, biomaterial scaffolds, matrices, fibers, coatings, hydrogels, and nanoparticles constitute an area of intensive research. Biomaterial-supported drug delivery has the advantage of tunable mechanical properties, biodegradability, and controllable drug release. Depending on the scaffold type, it can also offer the possibility of localized targeted treatment which allows reducing off-target effects. Biomaterial-supported drug delivery thus represents an important step toward the development of personalized and regenerative therapies.
Therapeutic response to systemically-administered drugs is a common problem in CVD and other disorders. Apart from limited efficacy and/or poor bioavailability, pharmacological therapies are often burdened by low tolerability. Intravascular drug delivery systems developed by encapsulating drugs in a nanoscale biomaterial-based shell are expected to increase drug circulation time, as well as improve safety and availability. Biomaterial-based, degradable drug delivery scaffolds may on the other hand enable localized therapies, improve treatment efficacy, minimize systemic and local toxicity, and enhance tissue regeneration. Biomaterial-supported drug delivery systems are therefore expected to have great therapeutic potential in CVD and other human diseases.
This Research Topic invites articles about biomaterial-supported drug delivery approaches, in particular addressing cardiovascular disorders, or that can be potentially used in CVD. Manuscripts describing bio-material scaffolds, hydrogels, and nanoparticles that enable either local or systemic drug delivery are sought. In particular, we welcome submissions with translational potential.
Submissions are welcome for the following article types: original research, review, mini-reviews, research protocol/method, opinion, and hypotheses.
Therapeutic response to systemically-administered drugs is a common problem in CVD and other disorders. Apart from limited efficacy and/or poor bioavailability, pharmacological therapies are often burdened by low tolerability. Intravascular drug delivery systems developed by encapsulating drugs in a nanoscale biomaterial-based shell are expected to increase drug circulation time, as well as improve safety and availability. Biomaterial-based, degradable drug delivery scaffolds may on the other hand enable localized therapies, improve treatment efficacy, minimize systemic and local toxicity, and enhance tissue regeneration. Biomaterial-supported drug delivery systems are therefore expected to have great therapeutic potential in CVD and other human diseases.
This Research Topic invites articles about biomaterial-supported drug delivery approaches, in particular addressing cardiovascular disorders, or that can be potentially used in CVD. Manuscripts describing bio-material scaffolds, hydrogels, and nanoparticles that enable either local or systemic drug delivery are sought. In particular, we welcome submissions with translational potential.
Submissions are welcome for the following article types: original research, review, mini-reviews, research protocol/method, opinion, and hypotheses.
Keywords: Biomaterials, natural materials, polymer-based drug delivery, nanocarriers, engineered scaffolds for drug release, precision drug delivery, enzyme-activated drug delivery systems, cardiac patches, stents, atherosclerosis, myocardial infarction
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
