About this Research Topic
The acquisition of the gut by various microbes in a time-critical and progressive manner is vital in driving the proper development and function of the gut epithelium and immune system. Failure of crucial bacteria to colonise at critical developmental stages can lead to impaired gut integrity and poor immune function. Furthermore, prolonged dysbiosis can lead to acute/chronic inflammation and high susceptibility to infection.
The colonisation of the gut depends on multiple interdependent factors, including host and microbial genetics and bioactive factors, environment, antibiotics, and nutrition and nutritional factors. While a healthy regime, and lifestyle is a generally recommended approach to help in maintaining gut and immune function, a comprehensive understanding on how specific bioactive diets products can promote colonisation of the gut by potentially health-promoting bacteria and counteract the debilitation effects of dysbiosis on host gut inflammation and susceptibility is lacking.
In this Research Topic, we welcome Original Research articles, Technology Reports, Reviews, Brief Research Reports, and Mini Reviews that cover, but are not limited to, the following areas:
1 Current research on colonisation of the human intestine and modulation of healthy gut and immune function.
2 Preclinical studies on use of well-defined dietary products to modulate gut microbiome and enhance resistance to disorders such as pathogen infections.
3 Preclinical studies on use of probiotics [single or multiples], alone or in combination with prebiotics, postbiotics, and synbiotics, to modulate the gut microbiome and enhance resistance to disorders such as pathogen infections.
4 Preclinical studies on use of host-derived live-biotherapeutic products to modulate the gut microbiome and enhance resistance to disorders such as pathogen infections.
5 Studies done on pathogen/commensal bacterial interactions within the healthy or disturbed microbiota of mouth, lung, skin, vagina, urinary tract and other non-intestinal epithelia.
6. Studies aiming to increase awareness regarding the key role of microbiota in maintaining a good health balance and wellbeing.
Keywords: Pathogen infection, host susceptibility, dysbiosis, epithelial and immune function, modulation of resident microbes, use of probiotics and live biotherapeutic products, host-pathogen interaction, microbiome
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.