About this Research Topic
Malignant primary brain tumors affect approximately 30% of all primary brain tumors diagnosed annually in the United States. Despite progress in multimodality treatment, the prognosis for this devastating disease remains dismal. The intratumoral heterogeneity of malignant brain tumors often leads to a complex molecular metabolic reprogramming in the tumor microenvironment, resulting in treatment resistance and tumor relapse.
Recent studies have shed light on the role of ferroptosis in tumorigenesis. Ferroptosis is an iron-dependent form of regulated cell death. This mechanism may play a pivotal role because it may promote a positive impact on oxidative stress and treatment resistance. Although ferroptosis may have a therapeutic potential towards malignant brain tumors, the underlying mechanisms and regulators still remain unknown. Little study has yet been devoted to this process. Therefore, ferroptosis induction may be a promising treatment target. Understanding the mechanisms of ferroptosis, in particular, its role in malignant brain tumors can help to enhance neuro oncological treatments.
The goal of this Research Topic is to provide a comprehensive overview of the role of ferroptosis in brain tumor development/progression, tumor recurrence, immune and tumor microenvironment as well as its therapeutical potential.
We would like to welcome submissions in the form of Original Research Articles, Reviews and/or Mini-Reviews focused on, but not limited to, the following topics:
• Biochemical, molecular, genomic, and proteomic studies related to ferroptosis in primary malignant or benign brain tumors (e. g. glioblastoma, medulloblastoma, meningioma)
• Clinical studies demonstrating potential targets for ferroptosis in the treatment of adult or pediatric brain tumors
• In vitro, ex vivo and in vivo tumor-related models analyzing the tumor and immune microenvironment and response to targeted cancer therapies in primary and secondary intracranial tumors (e. g. glioma, metastasis, lymphoma, chordoma etc.)
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Recent studies have shed light on the role of ferroptosis in tumorigenesis. Ferroptosis is an iron-dependent form of regulated cell death. This mechanism may play a pivotal role because it may promote a positive impact on oxidative stress and treatment resistance. Although ferroptosis may have a therapeutic potential towards malignant brain tumors, the underlying mechanisms and regulators still remain unknown. Little study has yet been devoted to this process. Therefore, ferroptosis induction may be a promising treatment target. Understanding the mechanisms of ferroptosis, in particular, its role in malignant brain tumors can help to enhance neuro oncological treatments.
The goal of this Research Topic is to provide a comprehensive overview of the role of ferroptosis in brain tumor development/progression, tumor recurrence, immune and tumor microenvironment as well as its therapeutical potential.
We would like to welcome submissions in the form of Original Research Articles, Reviews and/or Mini-Reviews focused on, but not limited to, the following topics:
• Biochemical, molecular, genomic, and proteomic studies related to ferroptosis in primary malignant or benign brain tumors (e. g. glioblastoma, medulloblastoma, meningioma)
• Clinical studies demonstrating potential targets for ferroptosis in the treatment of adult or pediatric brain tumors
• In vitro, ex vivo and in vivo tumor-related models analyzing the tumor and immune microenvironment and response to targeted cancer therapies in primary and secondary intracranial tumors (e. g. glioma, metastasis, lymphoma, chordoma etc.)
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords: Ferroptosis, Brain tumor, Glioblastoma, Metabolism, Drug resistance, Immune Microenvironment, Tumor microenvironment, Brain edema, SLC7A11, Oxidative stress
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
