About this Research Topic
The incidence of chronic respiratory diseases that affect adults and children increases year by year. Although the mortality and morbidity of many respiratory diseases is unclear, the World Health Organisation has estimated that approximately 400 million people globally are suffering from mild and moderate conditions of diseases like Asthma and COPD. The death toll from these diseases is beyond 1 million annually. In addition to its high death toll, Respiratory disorders account for 10% of total disability adjusted life years in the workforce.
Respiratory diseases are extremely complex, driven by interactions within the host-environment and presented by inflammatory, structural and functional abnormalities that vary over time. Integrative approaches allow the study of the lung as a complex system, taking into account the large number of subunits and their interactions found within the biological system. Respiratory diseases have a broad clinical spectrum, and they can be caused by many genetic, pharmacological, biological and/or immunological mechanisms. This heterogeneity has led to the use of precision medicine, requiring several different diagnostic and therapeutic approaches. Systems Biology allows holistic approaches to these diseases, combining data from genomic, transcriptomic and proteomic studies to design novel drugs and therapies for respiratory diseases.
This research topic welcomes original research articles, reviews and methods articles covering, but not restricted to, the following aspects:
- Immunological mechanisms underlying respiratory diseases
- Novel algorithms to predict patient outcomes upon treatment for respiratory diseases such as Asthma and COPD
- Analyses of gene regulatory or protein interaction networks within these diseases.
- Identification and validation of biomarkers of these diseases using machine learning approaches
Topic Editor Anthony Bosco is a co-inventor on a patent application that is related to this work. Anthony Bosco is a co-founder, equity holder, and director of the startup company Respiradigm Pty Ltd and the subsidiary First Breath Health Pty Ltd that is related to this work. Anthony Bosco is the founder of the startup company INSiGENe Pty Ltd that is unrelated to this work. All other Topic Editors declare no Conflicts of Interest with the Topic.
Respiratory diseases are extremely complex, driven by interactions within the host-environment and presented by inflammatory, structural and functional abnormalities that vary over time. Integrative approaches allow the study of the lung as a complex system, taking into account the large number of subunits and their interactions found within the biological system. Respiratory diseases have a broad clinical spectrum, and they can be caused by many genetic, pharmacological, biological and/or immunological mechanisms. This heterogeneity has led to the use of precision medicine, requiring several different diagnostic and therapeutic approaches. Systems Biology allows holistic approaches to these diseases, combining data from genomic, transcriptomic and proteomic studies to design novel drugs and therapies for respiratory diseases.
This research topic welcomes original research articles, reviews and methods articles covering, but not restricted to, the following aspects:
- Immunological mechanisms underlying respiratory diseases
- Novel algorithms to predict patient outcomes upon treatment for respiratory diseases such as Asthma and COPD
- Analyses of gene regulatory or protein interaction networks within these diseases.
- Identification and validation of biomarkers of these diseases using machine learning approaches
Topic Editor Anthony Bosco is a co-inventor on a patent application that is related to this work. Anthony Bosco is a co-founder, equity holder, and director of the startup company Respiradigm Pty Ltd and the subsidiary First Breath Health Pty Ltd that is related to this work. Anthony Bosco is the founder of the startup company INSiGENe Pty Ltd that is unrelated to this work. All other Topic Editors declare no Conflicts of Interest with the Topic.
Keywords: Respiratory Disease, COPD, Asthma
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
