About this Research Topic
Autophagy, an evolutionarily conserved cellular process, plays a pivotal role in maintaining cellular homeostasis by facilitating the degradation of damaged or dysfunctional cellular components. Perturbations in autophagy have been associated with various pathological conditions, including cancer. In recent years, there has been a surge of interest in investigating the modulation of autophagy as a potential strategy to treat cancer.
With this Research Topic, we aim to consolidate current knowledge, stimulate scientific discourse, and provide a platform for the dissemination of novel findings and future directions in the field of autophagy modulation for cancer treatment. We invite researchers and clinicians to contribute manuscripts that explore the intricate involvement of autophagy in cancer progression and discuss the rationale for targeting autophagy as a therapeutic approach. We encourage the submission of manuscripts analysing the function of particular autophagy subtypes such as chaperone-mediated autophagy (CMA), microautophagy or non-canonical autophagy such as conjugation of ATG8 to endolysosomal single membranes (CASM). In this respect, manuscripts focusing on the molecular mechanisms governing autophagy regulation, its interplay with other cellular processes such as apoptosis and senescence, and its potential crosstalk with the tumor microenvironment are welcome.
Additionally, we encourage submissions of studies that investigate the use of (novel) autophagy modulating agents for cancer therapy. Manuscripts that critically evaluate preclinical and clinical evidence supporting the concept of autophagy modulation as a complementary or standalone strategy in cancer therapy are also of interest in which we encourage authors to address the challenges associated with autophagy-targeting therapies and propose innovative approaches to enhance their efficacy.
This Research Topic aims to compile original research articles, comprehensive reviews, and cutting-edge perspectives on the topic of autophagy modulation in the context of cancer treatment.
With this Research Topic, we aim to consolidate current knowledge, stimulate scientific discourse, and provide a platform for the dissemination of novel findings and future directions in the field of autophagy modulation for cancer treatment. We invite researchers and clinicians to contribute manuscripts that explore the intricate involvement of autophagy in cancer progression and discuss the rationale for targeting autophagy as a therapeutic approach. We encourage the submission of manuscripts analysing the function of particular autophagy subtypes such as chaperone-mediated autophagy (CMA), microautophagy or non-canonical autophagy such as conjugation of ATG8 to endolysosomal single membranes (CASM). In this respect, manuscripts focusing on the molecular mechanisms governing autophagy regulation, its interplay with other cellular processes such as apoptosis and senescence, and its potential crosstalk with the tumor microenvironment are welcome.
Additionally, we encourage submissions of studies that investigate the use of (novel) autophagy modulating agents for cancer therapy. Manuscripts that critically evaluate preclinical and clinical evidence supporting the concept of autophagy modulation as a complementary or standalone strategy in cancer therapy are also of interest in which we encourage authors to address the challenges associated with autophagy-targeting therapies and propose innovative approaches to enhance their efficacy.
This Research Topic aims to compile original research articles, comprehensive reviews, and cutting-edge perspectives on the topic of autophagy modulation in the context of cancer treatment.
Keywords: autophagy, cancer, chemotherapy, cell death, cellular homeostasis, apoptosis
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
