About this Research Topic
Gut microbiome, a complex microbial community intricately linked to human health and immune function, has garnered increasing attention in recent years. Research has demonstrated the vital role of the gut microbiome in maintaining immune balance and preventing inflammatory diseases, wherein immune dysregulation serves as a central mechanism. An imbalance in gut microbiota composition is considered a critical factor contributing to immune dysregulation.
A dynamic interplay exists between the gut microbiome and the immune system. On one hand, the gut microbiome interacts with the host's immune system, regulating the development and function of immune cells. On the other hand, gut microbiota promotes immune system maturation and function by producing short-chain fatty acids, influencing T-cell differentiation, and stimulating immunoglobulin production. Disruption of gut microbiota is closely associated with immune dysregulation, often leading to inflammatory diseases such as inflammatory bowel disease, autoimmune conditions like rheumatoid arthritis and systemic lupus erythematosus, and allergic disorders including allergic rhinitis and asthma. Numerous studies have highlighted the close relationship between alterations in gut microbiota and the occurrence and progression of these inflammatory diseases.
In recent years, the gut microbiome has emerged as a potential therapeutic target for modulating inflammation. By manipulating the composition and function of the gut microbiome, it becomes possible to restore immune balance and alleviate inflammatory reactions. Interventions for gut microbiota include probiotic and prebiotic supplementation, faecal microbiota transplantation, and antibiotic use. These approaches have shown promise in the treatment of inflammatory diseases and continue to be refined and expanded.
Understanding the intricate relationship between the gut microbiome and inflammation resulting from immune dysregulation holds significant implications for the prevention and treatment of inflammatory diseases. This study aims to further explore the mechanisms underlying the interplay between the gut microbiome and inflammatory diseases while seeking novel intervention strategies to promote gut microbiome health and immune balance. The goal is to provide new insights and methodologies for the prevention and treatment of inflammatory diseases. We invite Original Research, Brief Reports, Reviews, Mini-Reviews, Methods, Viewpoints, and Opinion articles encompassing, but not limited to, the following topics:
- Gut microbiota composition and inflammation: Investigating the relationship between gut microbiota composition and inflammation, including associations between specific microbial communities (increased or decreased) and inflammatory diseases, as well as disparities in bacterial composition among different inflammatory conditions.
- Gut microbiota metabolites and immune dysregulation: Examining the interactions between gut microbiota metabolites (such as short-chain fatty acids, bile acids, and vitamins) and the immune system, exploring their roles in the onset and progression of inflammation.
- Gut microbiota-immune cell interactions: Exploring the interplay between gut microbiota and immune cells (e.g., macrophages, T cells, and B cells), investigating the impact of microbiota on immune cell differentiation, function, and regulation.
- Mechanisms of gut microbiota in inflammatory disease onset and progression: Conducting in-depth studies on the mechanisms underlying the development of inflammatory diseases (e.g., inflammatory bowel disease, autoimmune diseases, and allergic diseases), including the reciprocal influence of gut microbiota and immune dysregulation, as well as the modulation of inflammatory mediators.
- Therapeutic strategies for gut microbiome regulation: Discussing the application of interventions aimed at regulating the gut microbiome, such as probiotics, prebiotics, and fecal microbiota transplantation, in addressing inflammatory diseases caused by immune dysregulation. Furthermore, exploring their effectiveness and mechanisms in different inflammatory conditions.
A dynamic interplay exists between the gut microbiome and the immune system. On one hand, the gut microbiome interacts with the host's immune system, regulating the development and function of immune cells. On the other hand, gut microbiota promotes immune system maturation and function by producing short-chain fatty acids, influencing T-cell differentiation, and stimulating immunoglobulin production. Disruption of gut microbiota is closely associated with immune dysregulation, often leading to inflammatory diseases such as inflammatory bowel disease, autoimmune conditions like rheumatoid arthritis and systemic lupus erythematosus, and allergic disorders including allergic rhinitis and asthma. Numerous studies have highlighted the close relationship between alterations in gut microbiota and the occurrence and progression of these inflammatory diseases.
In recent years, the gut microbiome has emerged as a potential therapeutic target for modulating inflammation. By manipulating the composition and function of the gut microbiome, it becomes possible to restore immune balance and alleviate inflammatory reactions. Interventions for gut microbiota include probiotic and prebiotic supplementation, faecal microbiota transplantation, and antibiotic use. These approaches have shown promise in the treatment of inflammatory diseases and continue to be refined and expanded.
Understanding the intricate relationship between the gut microbiome and inflammation resulting from immune dysregulation holds significant implications for the prevention and treatment of inflammatory diseases. This study aims to further explore the mechanisms underlying the interplay between the gut microbiome and inflammatory diseases while seeking novel intervention strategies to promote gut microbiome health and immune balance. The goal is to provide new insights and methodologies for the prevention and treatment of inflammatory diseases. We invite Original Research, Brief Reports, Reviews, Mini-Reviews, Methods, Viewpoints, and Opinion articles encompassing, but not limited to, the following topics:
- Gut microbiota composition and inflammation: Investigating the relationship between gut microbiota composition and inflammation, including associations between specific microbial communities (increased or decreased) and inflammatory diseases, as well as disparities in bacterial composition among different inflammatory conditions.
- Gut microbiota metabolites and immune dysregulation: Examining the interactions between gut microbiota metabolites (such as short-chain fatty acids, bile acids, and vitamins) and the immune system, exploring their roles in the onset and progression of inflammation.
- Gut microbiota-immune cell interactions: Exploring the interplay between gut microbiota and immune cells (e.g., macrophages, T cells, and B cells), investigating the impact of microbiota on immune cell differentiation, function, and regulation.
- Mechanisms of gut microbiota in inflammatory disease onset and progression: Conducting in-depth studies on the mechanisms underlying the development of inflammatory diseases (e.g., inflammatory bowel disease, autoimmune diseases, and allergic diseases), including the reciprocal influence of gut microbiota and immune dysregulation, as well as the modulation of inflammatory mediators.
- Therapeutic strategies for gut microbiome regulation: Discussing the application of interventions aimed at regulating the gut microbiome, such as probiotics, prebiotics, and fecal microbiota transplantation, in addressing inflammatory diseases caused by immune dysregulation. Furthermore, exploring their effectiveness and mechanisms in different inflammatory conditions.
Keywords: Inflammation, Microbiome, Immunity, Gut microbiota
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