About this Research Topic
Macrophages play a crucial role in the innate immune system and contribute to the pathogenesis of various lung diseases, such as asthma, chronic obstructive pulmonary disease (COPD), acute lung injury (ALI), and pulmonary fibrosis. Macrophage activation involves multiple processes, including alterations in gene expression, protein production, and cellular metabolism. Recently, epigenetic modifications, including DNA methylation, histone modifications, and non-coding RNAs, have emerged as critical regulators of macrophage activation during lung disease pathogenesis. For instance, DNA methylation of genes regulating immune responses, such as IL-6 and TNF-α, has been found to be altered in macrophages from patients with COPD. Furthermore, histone modifications, such as acetylation and methylation, have been identified as regulators of macrophage activation in response to various stimuli.
Understanding the role of epigenetics in macrophage activation during the development of lung diseases is essential for the development of new therapeutic interventions. Therefore, this research topic aims to bring together experts in the field to review the current state of knowledge regarding the epigenetic regulation of macrophage activation in lung disease and to identify new avenues for future research. By investigating the underlying mechanisms that modulate macrophage activation during lung diseases, we can identify potential therapeutic targets and develop novel treatment strategies for these debilitating conditions.
We welcome submissions of original research, clinical trials, literature reviews, systematic reviews, short reports, and comments, on the subtopics of the following, but are not limited to:
1) The molecular mechanisms underlying epigenetic regulation of macrophage activation in lung diseases (such as asthma, COPD, ALI, pulmonary hypertension, lung cancer, and pulmonary fibrosis).
2) The impact of DNA methylation, histone modifications, and non-coding RNAs on macrophage activation.
3) Single-cell RNA sequencing reveals the changes in the macrophage during lung disease development.
4) Development of novel epigenetic-based therapies for lung diseases and translation from bench to bedside.
Understanding the role of epigenetics in macrophage activation during the development of lung diseases is essential for the development of new therapeutic interventions. Therefore, this research topic aims to bring together experts in the field to review the current state of knowledge regarding the epigenetic regulation of macrophage activation in lung disease and to identify new avenues for future research. By investigating the underlying mechanisms that modulate macrophage activation during lung diseases, we can identify potential therapeutic targets and develop novel treatment strategies for these debilitating conditions.
We welcome submissions of original research, clinical trials, literature reviews, systematic reviews, short reports, and comments, on the subtopics of the following, but are not limited to:
1) The molecular mechanisms underlying epigenetic regulation of macrophage activation in lung diseases (such as asthma, COPD, ALI, pulmonary hypertension, lung cancer, and pulmonary fibrosis).
2) The impact of DNA methylation, histone modifications, and non-coding RNAs on macrophage activation.
3) Single-cell RNA sequencing reveals the changes in the macrophage during lung disease development.
4) Development of novel epigenetic-based therapies for lung diseases and translation from bench to bedside.
Keywords: macrophage activation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
