About this Research Topic
Circadian rhythms are endogenous biological oscillations that have been observed in a variety of organisms, including plants, animals, fungi, and even photosynthetic bacteria. These rhythms are regulated by the expression of CLOCK genes, which maintain a 24-hour intracellular timekeeping cycle. These oscillations play a crucial role in maintaining sleep homeostasis and have a significant impact on physiology and behavior.
Chronobiology is an inherently multidisciplinary field that has been continuously evolving since its inception. Advances in high-throughput techniques have enabled the study of circadian rhythms on a systems level, with the use of computational and mathematical models to analyze their rhythmic properties and predict outcomes of aberrant rhythms. Dysregulated circadian rhythms can have far-reaching consequences on physiology, resulting in molecular dysfunctions that can contribute to various pathologies, including cardiovascular disease and cancer.
The aim of this research topic is to utilize a systems-level approach to elucidate the regulation of circadian rhythms and their impacts upon deregulation. We welcome studies that explore, but are not limited to:
- The role of circadian regulation in mammalian cell function, protein homeostasis, and metabolism at a systems level
- Utilization of mathematical models to study systematic circadian rhythms
- Clock-regulating genes and related pathways
- Role of the circadian clock in pathological conditions
- Integration of experimental and mathematical approaches to deconstruct complex regulatory processes
- Use of in silico experiments to describe molecular interactions in a systems biology model
By garnering a better understanding of circadian rhythms and their regulation, we hope to contribute to the development of new approaches in the prevention, diagnosis, and treatment of a multitude of circadian rhythm-associated diseases.
Topic Editor Pantelis Mavroudis is employed by Sanofi. All other Topic Editor declare no competing interests in regard to the Research Topic subject
Chronobiology is an inherently multidisciplinary field that has been continuously evolving since its inception. Advances in high-throughput techniques have enabled the study of circadian rhythms on a systems level, with the use of computational and mathematical models to analyze their rhythmic properties and predict outcomes of aberrant rhythms. Dysregulated circadian rhythms can have far-reaching consequences on physiology, resulting in molecular dysfunctions that can contribute to various pathologies, including cardiovascular disease and cancer.
The aim of this research topic is to utilize a systems-level approach to elucidate the regulation of circadian rhythms and their impacts upon deregulation. We welcome studies that explore, but are not limited to:
- The role of circadian regulation in mammalian cell function, protein homeostasis, and metabolism at a systems level
- Utilization of mathematical models to study systematic circadian rhythms
- Clock-regulating genes and related pathways
- Role of the circadian clock in pathological conditions
- Integration of experimental and mathematical approaches to deconstruct complex regulatory processes
- Use of in silico experiments to describe molecular interactions in a systems biology model
By garnering a better understanding of circadian rhythms and their regulation, we hope to contribute to the development of new approaches in the prevention, diagnosis, and treatment of a multitude of circadian rhythm-associated diseases.
Topic Editor Pantelis Mavroudis is employed by Sanofi. All other Topic Editor declare no competing interests in regard to the Research Topic subject
Keywords: CLOCK genes, Circadian Rhythm, Deregulation, Sleep Homeostasis, Chronobiology, High Through-Put Techniques, Mathematical Models, Cardiovascular Disease, Cancer
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
