Circadian rhythms are endogenous biological oscillations that have been observed in a variety of organisms, including plants, animals, fungi, and even photosynthetic bacteria. These rhythms are regulated by the expression of CLOCK genes, which maintain a 24-hour intracellular timekeeping cycle. These oscillations play a crucial role in maintaining sleep homeostasis and have a significant impact on physiology and behavior.

Chronobiology is an inherently multidisciplinary field that has been continuously evolving since its inception. Advances in high-throughput techniques have enabled the study of circadian rhythms on a systems level, with the use of computational and mathematical models to analyze their rhythmic properties and predict outcomes of aberrant rhythms. Dysregulated circadian rhythms can have far-reaching consequences on physiology, resulting in molecular dysfunctions that can contribute to various pathologies, including cardiovascular disease and cancer.

The aim of this research topic is to utilize a systems-level approach to elucidate the regulation of circadian rhythms and their impacts upon deregulation. We welcome studies that explore, but are not limited to:

- The role of circadian regulation in mammalian cell function, protein homeostasis, and metabolism at a systems level
- Utilization of mathematical models to study systematic circadian rhythms
- Clock-regulating genes and related pathways
- Role of the circadian clock in pathological conditions
- Integration of experimental and mathematical approaches to deconstruct complex regulatory processes
- Use of in silico experiments to describe molecular interactions in a systems biology model

By garnering a better understanding of circadian rhythms and their regulation, we hope to contribute to the development of new approaches in the prevention, diagnosis, and treatment of a multitude of circadian rhythm-associated diseases.

Topic Editor Pantelis Mavroudis is employed by Sanofi. All other Topic Editor declare no competing interests in regard to the Research Topic subject

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Frontiers in Systems Biology

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