About this Research Topic
Kidneys, sole blood filtering organs, supervise myriads of physiological functions such as the removal of waste products, maintaining homeostatic balance of water, salt and minerals and more. However, minute disruptions in the functionality of the kidney can result in renal ailments. Kidney disorders are a major global health concern, as testified by the exponential increase in cases of renal injuries in both community and hospital settings accompanied by high mortality, high morbidity, and healthcare costs. The domain of renal failure is much diversified. Acute and chronic renal failure are the two kinds of kidney failure more commonly described as Acute Kidney Injury (AKI) and Chronic Kidney Disease (CKD). Furthermore, injury stages have been categorized into prerenal, intrarenal and postrenal. AKI is often caused by events such as dehydration, blood loss or urinary tract infection while CKD is described as an aftermath of long-term debilitating conditions like diabetes, high blood pressure or genetic mutations e.g. in polycystin genes leading to ADPKD.
Although renal injury biomarkers can support diagnosis of the degree of ailment, a robust and continuous improvement in the present technological setup is needed. These can be broadly divided into early detection biomarkers, diagnostic biomarkers, and prognostic biomarkers. The next frontier in this area we envision is whether the artificial intelligence based (AI) methods can be further used to learn more about disease mechanisms and diagnosis.
The goal of this respective Research Topic is to provide thorough insights into latest developments in the arena of kidney injury and mechanisms of chronic kidney disease. We also aim to encompass mechanisms contributing to kidney injury such as inflammation, mitochondrial dysfunction, abnormal metabolism, and oxidative stress among others. New technologies have supported discovery of novel genes associated with kidney injury. We duly believe that the current topic will encapsulate literature that will offer guidance on future directions in the discovery and development of novel biomarkers and therapeutic options.
We will consider original research, brief reports and review articles covering the following themes:
• Mechanisms of kidney injury and chronic kidney diseases
• Genetic basis and mechanisms of chronic kidney diseases
• Novel biomarkers for chronic kidney diseases
• Recent advances in therapeutic approaches to treat kidney injury.
Although renal injury biomarkers can support diagnosis of the degree of ailment, a robust and continuous improvement in the present technological setup is needed. These can be broadly divided into early detection biomarkers, diagnostic biomarkers, and prognostic biomarkers. The next frontier in this area we envision is whether the artificial intelligence based (AI) methods can be further used to learn more about disease mechanisms and diagnosis.
The goal of this respective Research Topic is to provide thorough insights into latest developments in the arena of kidney injury and mechanisms of chronic kidney disease. We also aim to encompass mechanisms contributing to kidney injury such as inflammation, mitochondrial dysfunction, abnormal metabolism, and oxidative stress among others. New technologies have supported discovery of novel genes associated with kidney injury. We duly believe that the current topic will encapsulate literature that will offer guidance on future directions in the discovery and development of novel biomarkers and therapeutic options.
We will consider original research, brief reports and review articles covering the following themes:
• Mechanisms of kidney injury and chronic kidney diseases
• Genetic basis and mechanisms of chronic kidney diseases
• Novel biomarkers for chronic kidney diseases
• Recent advances in therapeutic approaches to treat kidney injury.
Keywords: renal failure, kidney injury, therapeutics, AKI, CKD
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
