About this Research Topic
Innovations in the field of genomics, phenomics, transcriptomics, proteomics, epigenomics, metabolomics, and microbiomics integrated with molecular informatics can be an appropriate methodology to develop novel prediction, prevention and treatment strategies for human diseases based on differences in people's genes, termed as Precision medicine, commonly referred as Personalized Medicine. One-size-fits-all-approach for treating patients is suitable strategy only for certain extant but not for all patients, as patients are unique in genetic makeup and influenced by the environmental factors, and lifestyle. Molecular informatics can target customized treatment strategies to reduce exposure to adverse effects and to achieve the goal of precision medicine, to identify “the right treatments to the right patients at the right time”. Integrated and standardised new technologies will be essential to ensure effective translation if the precision medicine is to become a reality for various human diseases.
This Research Topic aims to provide an in-depth overview of recent developments in customized treatment through molecular genetics, Single-cell analyses, phenomics, genomics, transcriptomics, proteomics, epigenomics, metabolomics, microbiomics and bioinformatics for reducing faulty science, invalid biomarkers to improve diagnostics. Genetic susceptibility refers to the tendency of distinct groups of people to be sensitive to certain diseases due to the presence of one or more genetic variants, characterized as life-threatening or chronically disabling diseases and are a severe public health burden. Advanced molecular informatics on collection of data, screening and prioritizing the disease-associated variations for in silico modeling and functional importance may help to overcome existing limitations. Comprehensive overview of recent advances in Molecular Informatics create numerous opportunities required for disease-related investigations to attain the vision of precision medicine.
Topics include but are not limited to:
• Long read sequencing and Next Generation Sequencing
• Computer-aided drug discovery (CADD) for developing possible drugs
• Molecular docking, virtual screening, modelling and dynamics simulations
This Research Topic aims to provide an in-depth overview of recent developments in customized treatment through molecular genetics, Single-cell analyses, phenomics, genomics, transcriptomics, proteomics, epigenomics, metabolomics, microbiomics and bioinformatics for reducing faulty science, invalid biomarkers to improve diagnostics. Genetic susceptibility refers to the tendency of distinct groups of people to be sensitive to certain diseases due to the presence of one or more genetic variants, characterized as life-threatening or chronically disabling diseases and are a severe public health burden. Advanced molecular informatics on collection of data, screening and prioritizing the disease-associated variations for in silico modeling and functional importance may help to overcome existing limitations. Comprehensive overview of recent advances in Molecular Informatics create numerous opportunities required for disease-related investigations to attain the vision of precision medicine.
Topics include but are not limited to:
• Long read sequencing and Next Generation Sequencing
• Computer-aided drug discovery (CADD) for developing possible drugs
• Molecular docking, virtual screening, modelling and dynamics simulations
Keywords: monogenic disorders, multiomics, precision medicine, drug discovery, rare diseases, molecular docking, modelling, dynamic simulation, next generation sequencing, epigenomics, molecular informatics
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