About this Research Topic
Although mouse developmental studies have significantly advanced our understanding of organogenesis, no existing technology has successfully generated functionally identical human organs solely from developmental programs. This highlights the need for continued exploration of the complexities of human development and the commonalities of stem cell behavior between humans and diverse animal models, which is essential for catalyzing advancements in biomedical and industrial applications.
The goal of this topic is to emphasize the significance of large animal models such as monkeys, bovines, swine, horses, dogs, cats, bears, sheep, whales, and ferrets. This topic will highlight their potential contributions to human development, regeneration, and disease modeling research. Addressing previously unexplored avenues within the biomedical and industrial sectors that rodent models insufficiently represent, large animal models can pave the way for breakthroughs in translational research. By facilitating the integration of diverse research approaches and promoting interdisciplinary collaboration, this section aims to offer a comprehensive understanding of the fundamental principles underlying human and large animal development and regeneration, ultimately accelerating progress in biomedical and industrial applications.
Rodent studies have been crucial in deepening our understanding of organogenesis and regenerative mechanisms. However, there are pronounced differences in progenitor identities and huge discrepancies of the anatomical structures compared to humans. To bioengineer or regenerate human-like tissues, studying with models that are evolutionarily or physiologically akin to humans is better. This emphasizes the urgent need to explore the complexities of development, regeneration further, and stem cell behavior in humans and larger animal models relative to humans, an endeavor crucial for advancing both biomedical and industrial fields.
Frontiers' forthcoming topic aims to consolidate core insights from research on human and large animal stem cells, emphasizing the underlying science of developmental and regenerative models in both domains. Key focus areas include: pluripotent stem cells, in vitro differentiation, tissue-specific cells, cellular reprogramming, bioengineering, regeneration, evolutionary perspectives, and comparative zoology, with a particular interest in comprehensively understanding the similarities and divergences between large animals and humans.
We welcome submissions spanning original research articles, concise reviews, in-depth reviews, translational studies, methodological insights, and single-cell bioinformatics incorporating wet-lab data. We value contributions that amalgamate or critically evaluate existing single-cell databases, ensuring meticulous quality checks to rectify past discrepancies.A full list of accepted article types, including descriptions, can be found at this link.
The goal of this topic is to emphasize the significance of large animal models such as monkeys, bovines, swine, horses, dogs, cats, bears, sheep, whales, and ferrets. This topic will highlight their potential contributions to human development, regeneration, and disease modeling research. Addressing previously unexplored avenues within the biomedical and industrial sectors that rodent models insufficiently represent, large animal models can pave the way for breakthroughs in translational research. By facilitating the integration of diverse research approaches and promoting interdisciplinary collaboration, this section aims to offer a comprehensive understanding of the fundamental principles underlying human and large animal development and regeneration, ultimately accelerating progress in biomedical and industrial applications.
Rodent studies have been crucial in deepening our understanding of organogenesis and regenerative mechanisms. However, there are pronounced differences in progenitor identities and huge discrepancies of the anatomical structures compared to humans. To bioengineer or regenerate human-like tissues, studying with models that are evolutionarily or physiologically akin to humans is better. This emphasizes the urgent need to explore the complexities of development, regeneration further, and stem cell behavior in humans and larger animal models relative to humans, an endeavor crucial for advancing both biomedical and industrial fields.
Frontiers' forthcoming topic aims to consolidate core insights from research on human and large animal stem cells, emphasizing the underlying science of developmental and regenerative models in both domains. Key focus areas include: pluripotent stem cells, in vitro differentiation, tissue-specific cells, cellular reprogramming, bioengineering, regeneration, evolutionary perspectives, and comparative zoology, with a particular interest in comprehensively understanding the similarities and divergences between large animals and humans.
We welcome submissions spanning original research articles, concise reviews, in-depth reviews, translational studies, methodological insights, and single-cell bioinformatics incorporating wet-lab data. We value contributions that amalgamate or critically evaluate existing single-cell databases, ensuring meticulous quality checks to rectify past discrepancies.A full list of accepted article types, including descriptions, can be found at this link.
Keywords: Human Stem Cells, Animal Stem Cells, Development, Pluripotent Stem Cell, Tissue Specific Stem Cells, In vitro Directed Differentiation, Blastocysts
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
