About this Research Topic
The field of metal-based compounds for therapeutic applications has garnered significant attention, particularly following the success of platinum-based drugs like cisplatin. This success has spurred extensive research into alternative metal-based therapeutic agents, driven by the potential for metal centres other than platinum to yield clinically useful drugs. The current challenge lies in discovering and characterizing new drugs that offer enhanced activity, selectivity, bioavailability, and fewer side effects compared to conventional treatments. Recent studies have highlighted the rich diversity and potential of metal complexes, which include unique properties such as intrinsic metal centres, characteristic coordination modes, accessible redox states, and tunable thermodynamic and kinetic properties. Despite these advances, there remains a need for a deeper understanding of the biological mechanisms of action and the development of novel therapeutic agents with improved efficacy and safety profiles.
This research topic aims to provide a contemporary perspective on the various therapeutic applications of metal-based compounds. The main objectives include exploring the synthesis and characterization of these compounds, understanding their biological mechanisms of action, and developing new strategies to enhance their therapeutic potential. Specific questions to be addressed include: What are the novel metal-based compounds with significant biological properties? How can these compounds be optimized to combat multidrug resistance and treat various diseases? What are the underlying mechanisms of action, and how can the pharmacokinetics and bioavailability of these drugs be improved?
To gather further insights into the therapeutic potential of metal-based compounds, we welcome original research articles, reviews, and perspective papers addressing, but not limited to, the following themes:
- Synthesis and characterization of metal-based compounds with biological properties (e.g., anticancer, antibacterial, antifungal, antiparasitic, anti-diabetes, anti-Alzheimer)
- Novel strategies involving metal-based compounds to combat multidrug resistance issues and for the treatment of diseases
- New approaches to enhance the therapeutic potential of existing, clinically used metal-based drugs
- Mechanisms of action of metal-based compounds
- Drug metabolism and pharmacokinetics (DMPK), imaging, or in vivo studies of metal-based compounds
This research topic aims to provide a contemporary perspective on the various therapeutic applications of metal-based compounds. The main objectives include exploring the synthesis and characterization of these compounds, understanding their biological mechanisms of action, and developing new strategies to enhance their therapeutic potential. Specific questions to be addressed include: What are the novel metal-based compounds with significant biological properties? How can these compounds be optimized to combat multidrug resistance and treat various diseases? What are the underlying mechanisms of action, and how can the pharmacokinetics and bioavailability of these drugs be improved?
To gather further insights into the therapeutic potential of metal-based compounds, we welcome original research articles, reviews, and perspective papers addressing, but not limited to, the following themes:
- Synthesis and characterization of metal-based compounds with biological properties (e.g., anticancer, antibacterial, antifungal, antiparasitic, anti-diabetes, anti-Alzheimer)
- Novel strategies involving metal-based compounds to combat multidrug resistance issues and for the treatment of diseases
- New approaches to enhance the therapeutic potential of existing, clinically used metal-based drugs
- Mechanisms of action of metal-based compounds
- Drug metabolism and pharmacokinetics (DMPK), imaging, or in vivo studies of metal-based compounds
Keywords: Metal-based compounds, Therapeutic agents, Bioinorganic chemistry, Drug metabolism and pharmacokinetics (DMPK), Alternative metal-based drugs
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
