Periodontal disease, a multifactorial and biofilm-induced inflammatory condition, has been increasingly linked to various systemic diseases, including cardiovascular diseases, respiratory tract diseases, diabetes mellitus, and conditions like preterm and low birth weight infants. These associations are primarily supported by epidemiological studies and the biological plausibility of periopathogenic bacteria entering the bloodstream and cytokines released from chronic periodontal inflammation. This connection suggests that periodontitis may act as a chronic low-grade inflammation, potentially increasing the risk of systemic diseases. Systemic diseases, particularly non-communicable diseases (NCDs), are the leading cause of death globally, accounting for two-thirds of all deaths. Severe periodontitis affects approximately 10-20% of the population, highlighting the need for effective prevention strategies. Despite the growing body of evidence, there remains a gap in understanding the full extent of the relationship between periodontal and systemic diseases, necessitating further investigation into preventive measures and management strategies.

This Research Topic aims to explore the potential of managing periodontal disease as a strategy to prevent or mitigate the onset and progression of systemic diseases. By focusing on the interplay between oral health and systemic conditions, the research seeks to answer critical questions about the effectiveness of periodontal disease management in reducing the incidence and severity of systemic diseases. The goal is to test hypotheses related to the impact of periodontal interventions on systemic health outcomes and to identify effective strategies for integrating oral health management into broader public health initiatives.

To gather further insights into the prevention of systemic diseases through periodontal disease management, we welcome articles addressing, but not limited to, the following themes:

- The role of periodontal disease in the pathogenesis of systemic diseases.

- Epidemiological studies linking periodontal health with systemic disease outcomes.

- Biological mechanisms underlying the connection between periodontal and systemic diseases.

- Interventional studies assessing the impact of periodontal treatment on systemic health.

- Public health strategies for integrating periodontal disease management into NCD prevention programs.

- Comparative analyses of different periodontal management approaches and their systemic health benefits.

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Frontiers in Oral Health

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