About this Research Topic
Polycystic ovary syndrome(PCOS) is a common endocrine disorder that primarily affects women of reproductive age. It is characterized by several clinical features such as decreased frequency of ovulation, irregular menstrual cycle, infertility, elevated male hormone levels (hyperandrogenism), causing excess facial hair (hirsutism), body hair, acne, and androgenic alopecia. Women with PCOS also experience insulin resistance (insulin insensitivity) and obesity, which are hallmarks of metabolic disorders such as type 2 diabetes mellitus (T2DM). It has also been reported that women with PCOS are more likely to experience psychological distress, including depression, anxiety, and social fear.
In this Research Topic, we aim to investigate the molecular basis of ovulation disorders and metabolic abnormalities. Through this investigation, we hope to identify the key factors and regulating networks associated with PCOS, which would provide valuable insight for developing potential treatment strategies.
This Research Topic is particularly focused on studies that investigate the pathogenesis of PCOS, and we encourage submissions that use comprehensive analyses and multiple orthogonal approaches to test a single research question. The following subtopics are suggested, but not limited to, for possible exploration:
• Molecular/cellular regulatory mechanisms of PCOS;
• Factors that affect the occurrence of PCOS (e.g., metabolism, circadian rhythm, sex hormones);
• Interdisciplinary studies of PCOS, such as endocrinology /developmental biology, reproductive medicine/neurology;
• Articles using the “Omics approach” will also be considered but must provide novel insights and in-depth analyses of targets or pathways to uncover the underlying molecular mechanisms of PCOS pathogenesis.
We welcome submissions of the following article types: Brief Research Report, Data Report, Mini Review, Original Research, Perspective, Review.
In this Research Topic, we aim to investigate the molecular basis of ovulation disorders and metabolic abnormalities. Through this investigation, we hope to identify the key factors and regulating networks associated with PCOS, which would provide valuable insight for developing potential treatment strategies.
This Research Topic is particularly focused on studies that investigate the pathogenesis of PCOS, and we encourage submissions that use comprehensive analyses and multiple orthogonal approaches to test a single research question. The following subtopics are suggested, but not limited to, for possible exploration:
• Molecular/cellular regulatory mechanisms of PCOS;
• Factors that affect the occurrence of PCOS (e.g., metabolism, circadian rhythm, sex hormones);
• Interdisciplinary studies of PCOS, such as endocrinology /developmental biology, reproductive medicine/neurology;
• Articles using the “Omics approach” will also be considered but must provide novel insights and in-depth analyses of targets or pathways to uncover the underlying molecular mechanisms of PCOS pathogenesis.
We welcome submissions of the following article types: Brief Research Report, Data Report, Mini Review, Original Research, Perspective, Review.
Keywords: polycystic ovary syndrome, pathogenesis, ovulation disorders, metabolic abnormalities, risk of depression, pregnancy outcomes
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
