About this Research Topic
Aging is a complex biological process influenced by both genetic and environmental factors. Epigenetic regulation plays a crucial role in modulating gene expression during aging. Non-histone post-translational modifications, such as acetylation, methylation, and phosphorylation, also affect protein function and stability during aging. Understanding the epigenetic and non-histone post-translational modifications involved in aging is essential for identifying novel therapeutic targets for age-related diseases.
Post-translational modifications (PTMs) are changes to proteins that help regulate their structure, function, and ability to clump together. These modifications can include things like adding or removing chemical groups, which affect how the protein behaves in the cell. When misfolded proteins aggregate, it can cause stress in the endoplasmic reticulum, which triggers a response from the cell. This response can lead to further disruptions in important cellular processes, including protein degradation, energy production, inflammation, and cell division. These disruptions can ultimately result in cell death, which is associated with neurodegenerative disorders.
This Research Topic invites contributions that explore the molecular mechanisms of epigenetic regulation and non-histone post-translational modifications in aging, including studies on the identification of novel epigenetic marks and the development of innovative techniques for studying epigenetic and non-histone post-translational modifications in aging.
Understanding the genetic and epigenetic regulation of human aging and lifespan can provide insights into the mechanisms of aging and age-related diseases. It can also help identify targets for modulating aging processes and improving healthspan interventions.
The goal of this Research Topic is to provide an overview of the current understanding and fundamental discoveries in the field of Epigenetic Regulation and Non-histone Post-translational Modification in Aging.
This article collection welcomes Original Research articles, Case Reports, (Mini)Reviews, Opinions, and Protocols that address (but are not limited to) the following aspects:
Integrated analysis of epigenetic regulation and non-histone posttranslational modification patterns across aging entities
The molecular mechanisms and pathways of epigenetic regulation and non-histone PTMs in aging
The interplay between epigenetics and non-histone PTMs in regulating cellular senescence
The role of epigenetics and non-histone PTMs in stem cell function and tissue regeneration
The impact of environmental factors (e.g., diet, stress) on epigenetics and non-histone PTMs in aging
The identification of epigenetic biomarkers for aging-related diseases
The development of novel therapeutic strategies based on epigenetic modulation or non-histone PTM manipulation for delaying aging or treating aging-related diseases
Post-translational modifications (PTMs) are changes to proteins that help regulate their structure, function, and ability to clump together. These modifications can include things like adding or removing chemical groups, which affect how the protein behaves in the cell. When misfolded proteins aggregate, it can cause stress in the endoplasmic reticulum, which triggers a response from the cell. This response can lead to further disruptions in important cellular processes, including protein degradation, energy production, inflammation, and cell division. These disruptions can ultimately result in cell death, which is associated with neurodegenerative disorders.
This Research Topic invites contributions that explore the molecular mechanisms of epigenetic regulation and non-histone post-translational modifications in aging, including studies on the identification of novel epigenetic marks and the development of innovative techniques for studying epigenetic and non-histone post-translational modifications in aging.
Understanding the genetic and epigenetic regulation of human aging and lifespan can provide insights into the mechanisms of aging and age-related diseases. It can also help identify targets for modulating aging processes and improving healthspan interventions.
The goal of this Research Topic is to provide an overview of the current understanding and fundamental discoveries in the field of Epigenetic Regulation and Non-histone Post-translational Modification in Aging.
This article collection welcomes Original Research articles, Case Reports, (Mini)Reviews, Opinions, and Protocols that address (but are not limited to) the following aspects:
Integrated analysis of epigenetic regulation and non-histone posttranslational modification patterns across aging entities
The molecular mechanisms and pathways of epigenetic regulation and non-histone PTMs in aging
The interplay between epigenetics and non-histone PTMs in regulating cellular senescence
The role of epigenetics and non-histone PTMs in stem cell function and tissue regeneration
The impact of environmental factors (e.g., diet, stress) on epigenetics and non-histone PTMs in aging
The identification of epigenetic biomarkers for aging-related diseases
The development of novel therapeutic strategies based on epigenetic modulation or non-histone PTM manipulation for delaying aging or treating aging-related diseases
Keywords: Aging, Epigenetic regulation, Non-histone post-translational modification
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
