The field of immunomodulation mediated by helminth infection or parasite-derived proteins is gaining significant attention due to its potential therapeutic applications. Helminths, a diverse group of parasitic worms, infect millions globally, causing diseases such as schistosomiasis, hookworm infection, and filariasis. While these infections are typically harmful, recent studies have highlighted their ability to beneficially modulate the host immune system. Helminths have evolved sophisticated mechanisms to evade host immunity, leading to chronic infections that can alter immune responses. Current research has shown that these interactions can potentially be harnessed to treat autoimmune diseases, allergies, and inflammatory disorders. However, the exact mechanisms by which helminths and their proteins modulate the immune system remain incompletely understood, necessitating further investigation.

This research topic aims to elucidate the complex interactions between the immune system and helminths or helminth-derived proteins, with a focus on their potential therapeutic applications. Specifically, the research will address questions such as: What are the mechanisms by which helminths modulate the immune system? How can helminth-derived proteins be used to treat autoimmune and inflammatory diseases? What are the roles of regulatory T cells, cytokines, and other immune cells in these processes? By answering these questions, the research aims to uncover novel therapeutic strategies and deepen our understanding of immune modulation.

To gather further insights into the boundaries of immunomodulation mediated by helminth infection or parasite-derived proteins, we welcome articles addressing, but not limited to, the following themes:
- Mechanisms by which helminth infections or derived proteins modulate the immune system
- Role of regulatory T cells, cytokines, and other immune cells in helminth-mediated immunomodulation
- Potential therapeutic applications of helminth-derived proteins in treating autoimmune diseases, allergies, and inflammatory disorders
- Comparative studies on the immunomodulatory effects of different helminth species
- Clinical trials and case studies on the use of helminth-derived proteins in medical treatments
- Molecular and cellular pathways involved in helminth-induced immune modulation
- Ethical and safety considerations in the therapeutic use of helminth-derived proteins

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Frontiers in Parasitology

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