About this Research Topic
Through this Research Topic, we would like to deepen various aspects regarding the involvement of vitamin C in the physio-pathological mechanisms of some diseases, as well as the possibilities of prevention and therapy of some functional and structural disturbances in the body. Starting from the finding of the existence of some correlations between the severity of some pathological conditions (infections, critical illnesses), and vitamin C deficiency, we want to explore the advantages of supplementation with this nutrient, as well as to decipher the involved mechanisms, mediators, enzyme systems, and to reveal some possible markers for assessing the evolution of these diseases.
Various other aspects could be targeted, such as those related to the protective role of vitamin C on the epigenetic disturbances of hematopoietic stem cells, the connection with the development and evolution of serious hematological diseases, and the possibility of potentiating the pharmacodynamics effects of cytostatic medication on the slowing down the malignant process progression. We would like to encourage researchers interested in this topic to disseminate the results of experiments carried out on laboratory animals, in vitro investigations, but also of clinical studies on the benefits and side effects that may occur when using vitamin C.
We welcome researchers to provide original research articles, as well as review or systematic review articles, focusing on multiple issues about the involvement of vitamin C in the pathophysiology of various diseases, the pharmacodynamics effects on different animal models of pathological conditions, the evidence of its clinical benefits, as well as recommendations for prophylactic and therapeutic use.
Keywords: vitamin C, immunity, antioxidant, dietary supplements
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.