Role of Skin in the Development of Food Allergy and Asthma

Allergies often develop early in life. Reports have indicated that the application of food allergens or environmental allergens on the skin can sensitize for the development of allergies or allergic asthma. Allergens stimulate immune cells and structural cells in the skin, including T cells, ILCs, mast cells, basophils, eosinophils, keratinocytes, fibroblasts, etc. These cells are activated or produce mediators for induction of cell mediated responses and the generation of allergen specific antibodies in follicles of draining lymph nodes.

This Research Topic aims to explore the regulation of skin responses and skin-derived mediators in the regulation of B cells in lymph node follicles which are needed to better define mechanisms for initiation of allergic disease by skin exposures to allergens.

Suitable themes for manuscripts include, but are not limited to:
● Skin epithelial factors that regulate T cells in follicle for IgE and initiation of allergy
● Treg cells in skin or follicles
● γδT cells in skin in response to allergen
● ILCs in skin
● Epithelial factors that regulate T cells, ILCs or lymph node follicles
● Th9 cells/skin
● Skin mast cell factors
● Eosinophils in the skin

All article types accepted by Frontiers in Allergy are welcome.

Keywords: Skin, food allergy, asthma, epithelial cells, T cells, ILCs, mast cells, eosinophils

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.