Crosstalk between Cell Death, Oxidative Stress, and Immune Regulation

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Background

Cell death, a biological event important for maintaining the growth, development, and life processes of organisms, mainly includes programmed death (apoptosis, pyroptosis, autophagy, mitochondrial apoptosis, ferroptosis, cuproptosis, and disulfidptosis, etc.) and non-programmed death (cell necrosis). Many diseases, including cancers, exhibit dysregulated immune activities as key features due to the increase in oxidative stress, which eventually leads to cell death. Understanding the intricate relationships between cell death, oxidative stress, and immune regulation could be critical in elucidating the key molecular mechanisms of these diseases, possibly uncovering novel therapeutics/diagnostics for disease management. For example, ferroptosis, a form of iron-dependent cell death that is triggered by the toxic accumulation of oxidative stress, can induce immunosuppression in tumor neutrophils, whereas inhibition of ferroptosis can slow tumor progression. For another example, pyroptosis, a form of lytic cell death which can be triggered by oxidative stress, when occurs in tumor cells, can induce a strong inflammatory response and significant tumor regression.

This special issue aims to present works that will contribute to the understanding of the crosstalk between cell death, oxidative stress, and immune regulation and their roles in disease development. For instance, whether all types of cell death involve oxidative stress response and immune regulation of the body? What role does the crosstalk between cell death, oxidative stress, and immune regulation play in disease development? Moreover, we also aim to encourage the development of novel drugs and probes, and new strategies targeting the “cell death-oxidative stress-immune modulation” pathways.

The purpose of this Research Topic is to use the current high-tech (e.g. olink proteomics, single-cell sequencing, and spatial transcriptomics) to explore the regulatory mechanisms in different types of cell death, to elucidate the intricate relationships between cell death, oxidative stress, and immune regulation in different diseases, as well as to encourage the discovery of novel therapeutics/diagnostics for management of the related diseases. We hope that these findings will enrich our understanding of the crosstalk between cell death, oxidative stress, and immune regulation, as well as open up new avenues for the treatment and diagnosis of human diseases, especially immune-related diseases.

We welcome the submission of Original Research, Methods, and Review articles that focus on, but are not limited to, the following areas:
(1) Mechanism of cell death and immune regulation.
(2) Mechanism of interaction between cell death and oxidative stress.
(3) The role of oxidative stress in cell death and immune regulation.
(4) Discovery of small molecule drugs targeting the “cell death-oxidative stress-immune regulation” signaling axis.
(5) Synthesis and application of bio-nanomaterials targeting the “cell death-oxidative stress-immune regulation” signaling axis.
(6) Discovery of diagnostic agents or probes targeting the “cell death-oxidative stress-immune regulation” signaling axis.
(7) Other topics related to “cell death-oxidative stress-immune regulation” are also welcome.

Keywords: Oxidative Stress, Cell Death, Immune Regulation

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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